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Curriculum(s) for 2024 - Industrial pharmacy (32355)

Single curriculum

1st year

LessonSemesterCFULanguage
10611078 | MATHEMATICS AND COMPUTER SCIENCE PRINCIPLES1st6ITA

Educational objectives

Ability to apply correctly and to address at a qualitative level - in the solution of problems - topics related to:
numerical calculation, data representation, sequences, algebraic calculation and analytical geometry, functions and their graphs,
derivatives, integrals, differential equations, probability.

10611079 | PLANT AND ANIMAL BIOLOGY1st6ITA

Educational objectives

General expected learning outcomes
The course aims to provide students with the foundational knowledge necessary to understand the subjects of subsequent years. Specifically, students will acquire knowledge about the types of molecules common to all living organisms, the cell, genetics, evolution, and ecology. The course offers an understanding of the main mechanisms of biological functioning at different levels of organization and the appropriate terminology for biology.

Specific expected learning outcomes
1. Knowledge and understanding
The student will understand all aspects related to the Chemistry of Life, starting from the elements that constitute biological molecules to the macromolecules essential for life; Cell Biology, with particular attention to the structure and function of prokaryotic and eukaryotic cells; Plant Biology, addressing the main botanical aspects of plant organisms; Formal Genetics and Molecular Biology, acquiring knowledge about nucleic acids, chromosomes, and the cell cycle; Animal Biology, gaining knowledge on general topics of animal organism biology through the study of model groups and the mechanisms of evolution: evolutionary changes in populations, speciation, and ecology.

2. Applying knowledge and understanding
By the end of the course, students will be able to classify various biological macromolecules and describe the structures and fundamental biological processes of cells and living organisms using appropriate scientific terminology. They will develop critical thinking skills in evaluating issues related to biology and the findings in the fields of plant and animal biology. The knowledge gained during the course will enable students to better understand the basic mechanisms that regulate living matter and organisms, facilitating the study of other biological subjects in their degree program.

3. Making judgements
The lecture will encourage students to develop a logical and critical sense, as well as the ability to connect the topics covered; these topics are not only closely interconnected but also related to the subjects that will be addressed in subsequent years. At the end of each module, there will be discussions on exercises that will help students assess their understanding and mastery of the material, with the aim of identifying and addressing any gaps or deficiencies.

4. Communication skills
The knowledge provided and the scientific language used by the lecture during the course will enable students to understand the topics covered in their degree program and to communicate with depth of knowledge and critical ability with peers and members of the scientific and social community, whether from similar or diverse cultural backgrounds.

5. Learning skills
The student who has acquired the above-mentioned skills will be able to undertake future studies in a more independent, self-managed, and efficient manner. They will also be capable of presenting topics useful for the scientific advancement of society in the field of human health in social and/or professional contexts.

10611080 | PHYSICS AND STATISTIC PRINCIPLES1st6ITA

Educational objectives

General expected learning outcomes
The Physics course aims to provide the student with a solid knowledge of the basis of the various branches (mechanics, thermodynamics, and electromagnetism) that constitute the so-called "classical physics." More generally, the student will learn to develop models and schemes based on appropriate simplifications and schematizations of a given physical system, allowing them to analyze and predict the system's
behavior using mathematical tools. Such skills, together with the notions of statistics provided during the course, will be extremely useful to the student in his future academic and professional career.

Specific expected learning outcomes
1. Knowledge and understanding
The student will learn the foundations of classical mechanics (kinematics, the three laws of Newton, conservation of energy and momentum, collisions, angular momentum, harmonic motion and waves, fluid dynamics), thermodynamics (temperature and the kinetic theory of gases, specific and latent heat, work, the first and the second law of thermodynamics,
thermodynamic transformations) and electromagnetism (charge, field and electric potential, Coulomb's law, Gauss's theorem, electric current, magnetic field, Lorentz's force, Biot-Savart's law, Ampere's theorem, Maxwell's equations, and electromagnetic waves. In addition, the course will provide the student with the mathematical and conceptual skills necessary for a deeper understanding of the subjects under study, including essential elements of statistics. At the end of the course, the student will have acquired a good knowledge of both conceptual and applicative aspects of physics, including notions of statistics.

2. Applying knowledge and understanding
Classical physics skills learned in the course—which can't be missing in the training baggage of anyone aspiring to a career in a scientific field— will go beyond mere notionism. In particular, every student will have to acquire and develop the tools, including statistical and probabilistic tools, necessary to apply what has been learned to the modeling and analysis of simple physical systems. This skill will be continually honed and tested through carrying out exercises, which will be proposed during the lessons and that will later constitute the written exam test. The latter, together with the oral exam described in point (4), will allow for an adequate and complete assessment of the level of skills achieved by the student.

3. Making judgements
The course aims, above all, to develop in the student the ability to critically analyze physical phenomena, using appropriate simplifications and schematizations as well as using the most suitable mathematical tools. This approach has always been at the root of the study of physics and is becoming increasingly valuable (and used) in other fields.
During the lessons, great attention will be devoted to emphasizing the points of contact between the subjects under study and the disciplines that form the backbone of the CTF study program, such as the biological, medical, and chemical-pharmaceutical disciplines. Great emphasis will also be given to developing the ability to use a scientific methodological approach to the study and research activities.

4. Communication skills
The student will have to be able to present the acquired knowledge clearly and directly. Specifically, the student must know how to process, interpret and rigorously present experimental data. The oral test, which, together with the written test described in point (2), will constitute the course's final exam, will cover all the topics of the program, allowing an adequate assessment of the ability of the student to communicate what was learned.

5. Learning skills
What is covered during the class can be found discussed and analyzed in detail in the reference textbook, which students must be able to consult with total autonomy. Consultation of other references is welcome. The student is encouraged to find and select other texts based on personal inclinations and preferences. This work of autonomous research will be helpful in the future when the memories of the lessons taught in the classroom will be nuanced, and it will be necessary to find the topics of one's interest in the sources available at any given time.

10611082 | GENERAL AND INORGANIC CHEMISTRY2nd8ITA

Educational objectives

General expected learning outcomes
The course aims to provide the student with a solid foundation in the fundamental concepts of chemistry, with particular reference to the chemistry of the elements, which will be the cultural heritage of the graduate in CTF. It deals with the indispensable topics for a correct understanding of matter and its transformations. On this basis it will be possible to found the skills that the student will have the opportunity to acquire in the courses of the following years. The course includes numerical exercises that make the student able to face the problems he/she will encounter in the various areas of chemistry, providing the essential tools for their analysis.

Specific expected learning outcomes
1. Knowledge and understanding
The student will have the opportunity to learn about general chemical structures and models, master the concepts underlying the properties and reactivity of matter, elements and chemical compounds, and understand the problems related to stoichiometry. He/she therefore knows the basic principles of general chemistry starting from the atomic structure, the periodic table and the chemical bond, up to chemical reactions (qualitative and quantitative aspects) with elements of kinetics and chemical thermodynamics and description of the aggregation states of matter. He/she is able to describe the equilibria (heterogeneous and homogeneous) and the fundamentals of electrochemistry. He/she will also have acquired a basic knowledge of the properties of the elements and their compounds.

2. Applying knowledge and understanding
Upon completion of the course the student will be able to correlate the various topics developed in the program by relating the properties of matter with the properties of atoms and molecules. He/she will also become familiar with the correct and appropriate application of calculation tools, using the disciplinary methods of investigation, in order to solve application questions.

3. Making judgements
The organization of the relevant exercises about the topics covered in the lectures will offer the student the opportunity to put to the test the knowledge acquired in relation to the various themes proposed. This allows to develop the ability to apply the concepts studied to practical cases and to critically evaluate the outcome and the method used in the procedures adopted.

4. Communication skills
In addition to providing basic knowledge, the course aims to make the student acquire mastery of language and appropriate use of chemical terminology and scientific method, essential for communicating in the national and international scientific context. To this end, ample space is dedicated to informal interventions and discussions during the lessons and to the oral exam.

5. Learning skills
The stimulus to use a correct scientific formalism and to formulate logically consistent deductions starting from the concepts and principles that underlie chemical science constitute a solid training towards cultural growth in the autonomy of future studies and professional activities.

1035933 | HUMAN ANATOMY2nd6ITA

Educational objectives

General expected learning outcomes
The general aim of the course is to provide students with basic knowledge of the morphology of the human body that will be necessary for the study of Physiology, Pathology and Pharmacology. At the end of the course students acquire an adequate knowledge of the anatomical nomenclature and terminology, as well as of the morphology, anatomical relationships and general organization of the different organs, apparatuses and systems of the human body.

Specific expected learning outcomes
1. Knowledge and understanding
The student will be able to identify and describe location and morphology of the organs of each system/apparatus of the human body. The student will be able to understand the terms and the names of common use in the anatomical language and will know how to link the above-mentioned terms and names to the right morpho-functional context.

2. Applying knowledge and understanding
At the end of the course, the student will be able to recognize and distinguish the different organs in the human body and be able to clearly attribute to them those macroscopic, microscopic and functional characteristics that distinguish the anatomical structures as they have been illustrated during the course of Human Anatomy. The anatomical relationships, the external morphology and the relationships between structure and function will be identified by the student at the end of the course basing on the acquisition of the method learned during the lessons, through the systematic examination of the characteristics of the human organs implemented by the teacher during the course itself.

3. Making judgements
The use of critical thinking will be developed through classroom discussions during face-to-face (frontal) and interactive lessons. The ability to reason on the exposed themes will also be enhanced through the discussion of morpho-functional aspects characteristic of the different systems and apparatuses of the human body. Thus, students will develop solid anatomical bases useful for the future study of disciplines such as Physiology, Pharmacology and General Pathology.

4. Communication skills
The evaluation of each student will be based on an oral test which will focus on questions concerning all the topics of the program. The student is required to answer the questions demonstrating clarity in the exposition of the topic, ability to synthesize and illustrate with a correct anatomical terminology the fundamental aspects of the macroscopic, microscopic and functional anatomy of the organs of the human body.

5. Learning skills
The student will find an in-depth description of the human body in the recommended textbooks. The recommended textbooks will remain as a fundamental reference point of the student, together with the notes get during the lessons, and they will continue to be considered a precious tool in the perspective of future other courses in the student’s academic path.

AAF1102 | English language2nd4ITA

Educational objectives

General expected learning outcomes
The course aims to provide the student with basic knowledge of scientific English, as well as the theoretical and practical basis for reading, analysing and writing a scientific text in English. The course aims to enable students to acquire B2 of the Common European Framework of Reference for Languages (CEFR).

Specific expected learning outcomes
1. Knowledge and understanding
The student will be familiar with all aspects of scientific communication in English, from basic terminology and language structures to the structure of scientific texts of various kinds (articles, reviews, abstracts etc.). The student will be able to identify the basic elements of scientific communication and critical thinking (prescriptive and descriptive issues, deductive and inductive reasoning, causal reasoning) and relate them to the various steps of the scientific method. The student will be able to distinguish and classify the various types of scientific publication (primary, secondary or tertiary level of information). Furthermore, the student will be able to analyse the different types of scientific publication by identifying their various parts (title, keywords, abstract, introduction, materials and methods, results, discussion, conclusions and bibliographical references) with their respective basic structural elements. The student will know how to conduct a bibliographical search using the main on-line databases and the tools made available by the Sapienza Library System.

2. Applying knowledge and understanding
At the end of the course, the student will have acquired the ability to identify and analyse the various types of scientific publications and their parts, identifying clarity and completeness with a critical eye. This basic knowledge will find an immediate application in the reading, analysis and comprehension of scientific texts of various kinds that will undoubtedly be needed as support and refresher material for courses in the years following the first. In addition, the foundations of critical thinking provided by the course will find application both in the study of other subjects (making connections between different topics, understanding the evolution of scientific thought on a single subject, etc.) and in practical activities in the laboratory. At the end of the course, the student will be able to write a short scientific text in English (scientific report, abstract, etc.), using the terminology and structural elements introduced in the course. The student will also be able to conduct a bibliographical research using the tools provided by the Sapienza library system, with particular attention to the choice of keywords and the selection of reliable bibliographical sources. These skills will find direct application in the drafting of laboratory reports and theses. All the tools provided by the course will be applied in the preparatory and ongoing study for the preparation of degree theses.

3. Making judgements
Lectures will be all interactive, in which the lecturer will ask students continuous questions to stimulate them and develop their logical-critical sense. Various exercises will be proposed during the lessons, to be carried out individually or in groups, with the aim of further encouraging the development of critical thinking and self-assessment also through comparison between the various students.

4. Communication skills
Questions and individual and group activities carried out in class will encourage and stimulate the ability to communicate what has been learnt during the course. These activities are also aimed at developing the ability to write short scientific texts in English. In addition, the activities carried out during the course will prepare students for communicative relationships in the academic and non-academic worlds of work and research with their peers.

5. Learning skills
The student will find the topics and related insights covered in class in the recommended texts and material made available by the lecturer. The texts and material received will remain the student's reference point also for their future use in the analysis and understanding of scientific articles both for university study and for future work applications.

Elective course2nd8ITA

Educational objectives

In addition to the compulsory courses, the study plan also includes, in the first year of the course, some activities chosen by the student. These activities, which can be autonomously chosen by the student within the entire educational offer of the Sapienza university, must however be consistent with the training objectives of the CTF degree course and must be submitted for approval by the Degree Program Board, except in the case in which the choice falls within the range of complementary courses and insight activities.

2nd year

LessonSemesterCFULanguage
10611081 | ORGANIC CHEMISTRY I1st8ITA

Educational objectives

General expected learning outcomes
Organic chemistry is a chemistry discipline involving the scientific study of the structure, reactivity, properties and applications of compounds which are formed mainly by carbon atoms, forming covalent bonds, both from natural and artificial sources. The general objective, is to provide students with the knowledge and competences necessary to understand the structure, reactivity and synthetic methods of different functional groups, and the mechanisms of organic reactions. For a CTF student, this learning is essential, because most drugs are organic compounds, and their biological activity depends on their interaction with biological targets, which are also organic compounds. This knowledge will allow the student to be able to understand the fundamental synthetic methodology for the construction of biologically active compounds. Furthermore, stereochemical expertise will be essential for improving the understanding of the drug-receptor interactions, a crucial topic in different next courses.

Specific expected learning outcomes
Organic chemistry is a chemistry discipline involving the scientific study of the structure, reactivity, properties and applications of compounds which are formed mainly by carbon atoms, forming covalent bonds, both from natural and artificial sources The general objective, is to provide students with the knowledge and competences necessary to understand the structure, reactivity and synthetic methods of different functional groups, and the mechanisms of organic reactions. For a CTF student, this learning is essential, because most drugs are organic compounds, and their biological activity depends on their interaction with biological targets, which are also organic compounds. This knowledge will allow the student to be able to understand the fundamental synthetic methodology for the construction of biologically active compounds. Furthermore, stereochemical expertise will be essential for improving the understanding of the drug-receptor interactions, a crucial topic in different next courses.

10612509 | ANALYTICAL CHEMISTRY AND COMPLEMENTS OF GENERAL AND INORGANIC CHEMISTRY1st8ITA

Educational objectives

General expected learning outcomes
This course completes the basic knowledge of the general chemistry acquired during the first year highlighting the interconnections and introduces students to some fundamental analytical disciplines/procedures that will be developed in detail in the following years according to the specific addresses of the degree course.

Specific expected learning outcomes
1. Knowledge and understanding
The student becomes aware of the interconnections between the different chemical and physical properties of the molecules and of the conditions in which these properties occur, or are inhibited, from the point of view of the regulation / control mechanisms of these properties. Particular attention is paid to the fundamental topics of chemistry (salts, acids and bases, solubility, redox processes, complexes), which having been the subject of the teaching of General Chemistry in the first year of the CdL in CTF, they are now shown in the optics of their application in laboratory activities.
The course includes the theoretical and applicative treatment of coordination compounds and the basics of nuclear chemistry, with particular reference to the production of artificial radioisotopes used in diagnostic and therapeutic nuclear medicine (radiopharmaceuticals).
Other knowledge acquired concern the statistical foundations of Analytical Chemistry for the treatment of measures and errors, and the criteria for the graphic representation of chemical-physical processes and phenomena, useful in the laboratory activities.
Finally, students receive basic training for the principles of chromatography and mass spectrometric methodologies.

2. Applying knowledge and understanding
At the end of the course the student will develop towards the fundamental aspects of chemical reactions and analytical chemistry, enough sensitivity to allow him to consciously deal with the subsequent courses of preparatory laboratory, quantitative analysis and separation of substances.

3. Making judgements
During the lessons, the critical and judgmental skills of the students are stimulated by their active participation, both through questions by the teacher, and through the collective solution of exercises representing real cases of problems that may occur in laboratory practice.

4. Communication skills
This ability emerges during the lessons, when the collective participation of the students is needed and finds the upper level during the examination, in which the student explains the logical motivations of the answers, also through the use of visual tools such as functional charts and histograms.

5. Learning skills
The student is induced to study autonomously not only by reading the recommended texts, but also by researching information through computer tools, especially for those topics treated only at an introductory level during the course, but that being historically consolidated they are described more in depth on specialized websites accessible through search engines.

ANALYTICAL CHEMISTRY1st4ITA

Educational objectives

General expected learning outcomes
This course completes the basic knowledge of the general chemistry acquired during the first year highlighting the interconnections and introduces students to some fundamental analytical disciplines/procedures that will be developed in detail in the following years according to the specific addresses of the degree course.

Specific expected learning outcomes
1. Knowledge and understanding
The student becomes aware of the interconnections between the different chemical and physical properties of the molecules and of the conditions in which these properties occur, or are inhibited, from the point of view of the regulation / control mechanisms of these properties. Particular attention is paid to the fundamental topics of chemistry (salts, acids and bases, solubility, redox processes, complexes), which having been the subject of the teaching of General Chemistry in the first year of the CdL in CTF, they are now shown in the optics of their application in laboratory activities.
The course includes the theoretical and applicative treatment of coordination compounds and the basics of nuclear chemistry, with particular reference to the production of artificial radioisotopes used in diagnostic and therapeutic nuclear medicine (radiopharmaceuticals).
Other knowledge acquired concern the statistical foundations of Analytical Chemistry for the treatment of measures and errors, and the criteria for the graphic representation of chemical-physical processes and phenomena, useful in the laboratory activities.
Finally, students receive basic training for the principles of chromatography and mass spectrometric methodologies.

2. Applying knowledge and understanding
At the end of the course the student will develop towards the fundamental aspects of chemical reactions and analytical chemistry, enough sensitivity to allow him to consciously deal with the subsequent courses of preparatory laboratory, quantitative analysis and separation of substances.

3. Making judgements
During the lessons, the critical and judgmental skills of the students are stimulated by their active participation, both through questions by the teacher, and through the collective solution of exercises representing real cases of problems that may occur in laboratory practice.

4. Communication skills
This ability emerges during the lessons, when the collective participation of the students is needed and finds the upper level during the examination, in which the student explains the logical motivations of the answers, also through the use of visual tools such as functional charts and histograms.

5. Learning skills
The student is induced to study autonomously not only by reading the recommended texts, but also by researching information through computer tools, especially for those topics treated only at an introductory level during the course, but that being historically consolidated they are described more in depth on specialized websites accessible through search engines.

COMPLEMENTS OF GENERAL AND INORGANIC CHEMISTRY1st4ITA

Educational objectives

General expected learning outcomes
This course completes the basic knowledge of the general chemistry acquired during the first year highlighting the interconnections and introduces students to some fundamental analytical disciplines/procedures that will be developed in detail in the following years according to the specific addresses of the degree course.

Specific expected learning outcomes
1. Knowledge and understanding
The student becomes aware of the interconnections between the different chemical and physical properties of the molecules and of the conditions in which these properties occur, or are inhibited, from the point of view of the regulation / control mechanisms of these properties. Particular attention is paid to the fundamental topics of chemistry (salts, acids and bases, solubility, redox processes, complexes), which having been the subject of the teaching of General Chemistry in the first year of the CdL in CTF, they are now shown in the optics of their application in laboratory activities.
The course includes the theoretical and applicative treatment of coordination compounds and the basics of nuclear chemistry, with particular reference to the production of artificial radioisotopes used in diagnostic and therapeutic nuclear medicine (radiopharmaceuticals).
Other knowledge acquired concern the statistical foundations of Analytical Chemistry for the treatment of measures and errors, and the criteria for the graphic representation of chemical-physical processes and phenomena, useful in the laboratory activities.
Finally, students receive basic training for the principles of chromatography and mass spectrometric methodologies.

2. Applying knowledge and understanding
At the end of the course the student will develop towards the fundamental aspects of chemical reactions and analytical chemistry, enough sensitivity to allow him to consciously deal with the subsequent courses of preparatory laboratory, quantitative analysis and separation of substances.

3. Making judgements
During the lessons, the critical and judgmental skills of the students are stimulated by their active participation, both through questions by the teacher, and through the collective solution of exercises representing real cases of problems that may occur in laboratory practice.

4. Communication skills
This ability emerges during the lessons, when the collective participation of the students is needed and finds the upper level during the examination, in which the student explains the logical motivations of the answers, also through the use of visual tools such as functional charts and histograms.

5. Learning skills
The student is induced to study autonomously not only by reading the recommended texts, but also by researching information through computer tools, especially for those topics treated only at an introductory level during the course, but that being historically consolidated they are described more in depth on specialized websites accessible through search engines.

1022761 | PHARMACEUTICAL AND TOXICOLOGICAL ANALYTICAL CHEMISTRY I1st10ITA

Educational objectives

General expected learning outcomes
The course aims to provide the students a theoretical and practical knowledge related to research and qualitative recognition of inorganic substances of pharmacological and toxicological interest. The aim of the course is also to provide the molecular mechanisms on the pharmaceutical and toxicological properties of the aforementioned substances.

Specific expected learning outcomes
1. Knowledge and understanding
The student will study all the aspects concerning the chemical reactions used for the separation and recognition of the cations included in the 6 groups of the classical systematic approach (group I: silver, lead and mercury; II group: lead, mercury, arsenic, antimony, tin, bismuth , copper, cadmium; III group: aluminium, iron, chrome, manganese; group IV: manganese, zinc, nickel, cobalt; V group: calcium, barium, strontium; group VI: magnesium, sodium, lithium, potassium) as well as anions identifiable by the research in the alkaline solution (sulphate, nitrate, chloride, bromide, iodide and oxalate). Moreover, the student will be able to apply theoretically/practically the concepts concerning the acid-base equilibria, hydrolysis, complexation, precipitation, redox reduction and be able to evaluate all the related interdependencies for the purpose of the recognition of inorganic compounds. Additionally, the student will be able to understand the molecular biological mechanisms in which cations and inorganic anions take part.

2. Applying knowledge and understanding
At the end of the course, the student will be able to separate and analyse an inorganic cation or anion mixture through the application and interpretation of chemical essays. For this purpose it will be essential to know and apply the different chemical reactivity for the separation and identification of the ions (changes in pH, complexation, precipitation and redox). The practical laboratory exercises will allow the student to learn how to apply and observe what was already covered during the lectures. Knowledge of the properties and reactivity of inorganic substances will allow the student not only to understand the biological, pharmacological and toxicological functions of these substances, but also to design and / or identify possible approaches for solving relative problems. The knowledge of the most widespread therapeutic problems and pharmaceutical solutions of inorganic type (essential micronutrient elements integrators) available for the treatment of the main pathologies associated with deficiency or intoxication will make the student able to make the right decision and to give rational advice for the use of these pharmaceuticals in the field of human health.

3. Making judgements
The lecturer will stimulate the students to develop a logical-critical sense by asking frequent questions (brainstorming) in class with the aim of inducing them to acquire connection skills (correlative thinking) between the various concepts defined in the syllabus leading to the mastery of the subject, connecting the chemical pharmaceutical and toxicological analysis as an integral part with a link to other disciplines already studied (general and inorganic chemistry, physics, anatomy, biology) or to be followed in the future educational path (biochemistry, physiology, pathology, pharmacology, pharmacognosy, toxicology). The lecturer will periodically ask students to develop discussions/theses related to key topics discussed in class, in order to get them used to design scientific research.
At the end of the course the students will be able to formulate an analytical/critical judgment, interpret and correlate complex concepts, design a research related to the topics covered in order to expand scientific, ethical and social knowledge.

4. Communication skills
Through the acquisition of knowledge and understanding, the ability to apply them and to propose a critical judgment on the topics dealt with, but also through the use of the relative scientific language used by the lecturer during the course and the frequent stimulation of the communication lesson, the student will be able to communicate with cognitive and linguistic-perceptive depth with his peers and/or with both the scientific and non-scientific community also of different cultural origin.

5. Learning skills
The student who has acquired the abilities described above will be able to undertake future studies in a more autonomous, self-managed and rapid manner, but also to propose social and/or working contexts useful for the scientific progress of society in the field of human health.

10611093 | GENERAL PHYSIOLOGY2nd7ITA

Educational objectives

General expected learning outcomes
At the end of the course students will know the basic physical principles and mechanisms that regulates cell physiology, with particular attention to the electrical properties of excitable cells and neuronal transmission; the function of the organs in the human body; the dynamical integration of the various organs into systems; the general mechanisms of functional control under normal conditions. The student will be aware of the main molecular and cellular mechanisms target of possible pharmacological treatments.

Specific expected learning outcomes
1. Knowledge and understanding
The student will know all the aspects of cellular and plasma membrane functioning, of the central and autonomic nervous system, of muscular contraction (skeletal smooth and cardiac muscle), of the cardiovascular system, of the respiratory system, of the urinary system, of the digestive system and of hormonal communication, and the regulation of the pH of the liquid compartments.

2. Applying knowledge and understanding
The student will know all the aspects of cellular and plasma membrane functioning, of the central and autonomic nervous system, of muscular contraction (skeletal smooth and cardiac muscle), of the cardiovascular system, of the respiratory system, of the urinary system, of the digestive system and of hormonal communication, and the regulation of the pH of the liquid compartments.

3. Making judgements
The lessons will be interactive; the professor will ask continuous questions to the students to stimulate them to develop critical sense and to integrate previous knowledge. These questions will also be used to evaluate and solicit students to make connections with the skills acquired previously, avoiding considering the study of the general physiology as self-standing, but integrating the physiology in the light of the knowledge already acquired (physical, chemical, biological, and anatomical).

4. Communication skills
The student will acquire the ability to communicate all the topics covered by the program and to expose them in an integrated perspective considering the correct functioning of the human organism. Eventually, students will be organized in small groups that will expose to the class oral presentations on specific topics related to the effect of drugs in regulating the physiological functions.

5. Learning skills
Recommended texts will provide a tool to integrate the knowledge acquired during the class. The texts will remain the reference point of the student who will know where to go to find the concepts in detail. He/she will be able to integrate these concepts with the materials available on specific online sites whose links will be suggested in class.

1008176 | BIOCHEMISTRY2nd10ITA

Educational objectives

General expected learning outcomes
To understand the role of macromolecules in cells or tissues;- To provide students with knowledge about biochemical basis of cellular and metabolic processes that occur in human body under both physiological and pathological conditions; -To develop skills in the assessment and evaluation of pathologic condition from data of biochemical analysis.

Specific expected learning outcomes
1. Knowledge and understanding
Upon completion of the Biochemistry course, the student increases his or her scientific knowledge in the chemistry of living organisms such as:
-relation between the structure and function of major biological molecules such as proteins, carbohydrates, lipids, nucleic acids and vitamins.
- the biochemical mechanism essential for the proper metabolic functioning of living organisms.
- Knowledge of the molecular mechanisms underlying diseases, useful for the pharmacological treatment of different diseases.

2. Applying knowledge and understanding
The knowledges gained provides the ability to apply these skills in many areas such as pharmaceutical chemistry, medicine, and environmental science. The course provides the brightest students with good problem-solving skills in this area such as identifying new molecular targets for the development of new therapeutic treatments and diagnostic techniques, including biotechnology-based ones, and excellent communication skills.

3. Making judgements
Ability to use a scientific methodological approach to study and research activities, exercising critical thinking and independent judgment.

4. Communication skills
During the lessons, the students will be involved in the discussion of the topics covered in order to check their understanding, and learning of the subject matter and develop effective communication skills

5. Learning skills
Students will acquire the ability to consult scientific bibliographic material and databases specific to the field, in order to maintain a continuous update of their professional knowledge and skills in relation to the advancement of the field both nationally and internationally.
Students will acquire skills to independently undertake more advanced studies.

1008199 | PHYSICAL CHEMISTRY2nd8ITA

Educational objectives

General expected learning outcomes
The course aims to provide students the information necessary for a critical knowledge of the principles and applications of physical chemistry ranging from classical thermodynamics to kinetics, electrochemistry and, in particular, to the thermodynamics of irreversible processes. I this way students will acquire the basis to understand some of the topics covered in the courses in the next years of biochemical, chemical pharmaceutical and pharmacological character, with particular regard to transport processes.

Specific expected learning outcomes
KNOWLEDGE AND UNDERSTANDING:
• to know the principles underlying physical chemistry about the thermodynamic, kinetic and thermodynamic treatment of irreversible processes;
• to be able to understand its potential and its use for the study of real systems, about the biological ones.

APPLYING KNOWLEDGE AND UNDERSTANDING:
• to understand the different theoretical-experimental approaches for the resolution of problems in the biochemical and pharmacological fields.

MAKING JUDGMENTS:
• to be able to develop their critical sense following stimuli coming from the teacher:
• to be able to link the topics studied thanks also to the multidisciplinary of the course by integrating the physical chemistry with the knowledge already acquired or to be acquired of the chemical type (inorganic, organic, biochemical chemistry) and biological (pharmacology and toxicology).

LEARNING SKILLS:
• To be able to describe scientific topics related to real systems using in a critical way the methodologies and techniques covered in the course.

COMMUNICATION SKILLS:
• To be able to discuss scientific topics related to physical chemistry and apply them to biological, pharmaceutical and pharmacological processes.

1022434 | MICROBIOLOGY2nd8ITA

Educational objectives

General expected learning outcomes
The course aims to provide students with a detailed knowledge of the main microrganisms of medical interest and their role in physiological and pathological processes in humans.
Particular attention will be paid to microorganism-host relationships, the mechanisms underlying infectious diseases and possible therapeutic and preventive approaches, as well as aspects of public and environmental hygiene.

Specific expected learning outcomes
1. Knowledge and understanding
At the end of the course, the student will know in depth the medical microbiology in its general and applicative aspects. In particular, the course will allow the student to acquire a good knowledge about morphological and physiological characteristics of bacteria, mycetes and protozoa of medical interest, their transmission, related diseases and underlying pathogenic mechanisms. Moreover, the student will know the structure and replication mechanisms of the main viruses of medical interest, the virus-host relationships, and pathogenic mechanisms. The student will also know the main elements of immune responses to microbial infections, as well as main therapeutic and diagnostic approaches.
Finally, the student will acquire knowledge related to the prevention and control of the spread of infectious agents.

2. Applying knowledge and understanding
The course will prepare the student to know and understand the main mechanisms of action of antimicrobial drugs and vaccines. Particular attention will be devoted to the antimicrobial resistance, underlying mechanisms, and related problems. The ability to use a scientific methodological approach to research activities will also be developed.

3. Making judgements
During the lessons the teacher will pursue an effective question strategy to capture students' attention, foster student involvement, and facilitate a positive, active learning environment.

4. Communication skills
At the end of the course the student will be able to use an appropriate technical-scientific language to communicate correctly on the topics covered, even with non-specialists or professionals from other disciplines.

5. Learning skills
The course is aimed at facilitating a critical and autonomous in-depth study of the topics covered in specialized texts and through consultation of databases and sector-specific platforms.

3rd year

LessonSemesterCFULanguage
1022762 | PHARMACEUTICAL AND TOXICOLOGICAL ANALYTICAL CHEMISTRY II1st10ITA

Educational objectives

General expected learning outcomes
The aim of Analisi Chimico Farmaceutica e Tossicologica II course is to contribute knowledge and ability about the quantitative determination of drugs and substances of pharmaceutical interest present in a more or less complex mixture,, as well as to make students aware of the importance of safety in experimental practice.

Specific expected learning outcomes
1. Knowledge and understanding
At the end of the course, the students will be familiar with the techniques of quantitative analysis for the determination of organic and inorganic compounds, they will acquired competences on how to perform volumetric, spectrophotometric, chromatographic and gravimetric analysis of compounds of pharmaceutical interest, applying appropriate analytical methods described European Pharmacopoeia. They will also have understood the concept of error in chemical analysis for the evaluation of acquired analytical data.

2. Applying knowledge and understanding
At the end of the course the students will be able to prepare solutions with a known concentration, perform calculations to determine the analyte content in unknown samples, choose the appropriate volumetric analysis method and know the optimal operating conditions, will be able to interpret the monographs present in the European Pharmacopoeia.

3. Making judgements
The students, through practical laboratory exercises, will be able to carry out the quantitative determination of a substance by autonomously managing their own laboratory activity and making use of the knowledge now acquired on quantitative analysis.
At the end of each practical exercise, the students will be able to independently draft a report on the laboratory experience in which they will describe the correct analytical procedure applied. Similar drug dosing exercises will be proposed during the examination.

4. Communication skills
Thanks to the numerous analyses carried out during practical laboratory exercises, the students will have acquired the confidence and ability to independently determine the quantity and purity of compounds and will be able to demonstrate the concepts through a written test and a subsequent oral interview.

5. Learning skills
The students will be able to independently learn all the analytical techniques thanks to the availability of texts and handouts; furthermore, they can complete their studies using their own laboratory notebook.

1008208 | ORGANIC CHEMISTRY II1st8ITA

Educational objectives

General expected learning outcomes
Organic chemistry is a chemistry discipline involving the scientific study of the structure, reactivity, properties and applications of compounds which are formed mainly by carbon atoms, forming covalent bonds, both from natural and artificial sources The general objective, is to provide students with the knowledge and competences necessary to understand the relationship between molecular structure and reactivity of the different functional groups, the mechanisms of organic reactions, the chemistry of heterocyclic compounds and biomolecules. For a CTF student, this learning is essential, because most drugs are organic compounds, and their biological activity depends on their interaction with biological targets, which are also organic compounds. This knowledge will allow the student to be able to understand the fundamental synthetic methodology for the construction heterocyclic compounds. Furthermore, stereochemical complements will be essential for improving the understanding of the drug-receptor interactions, a crucial topic in different next courses.

Specific expected learning outcomes
The Organic Chemistry 2 course is devoted to provide students with the adequate knowledge to be independent in solving problems about the main aspects of specific organic chemistry studies. This ability will be acquired by the means of frontal lesson submitting case studies of general interest.
Teaching materials, available on line will support students during the lessons even thought studying the recommended text book is essential to acquire the skills and the competence that are necessary to perform the final exam.
In order to improve the exposure ability, students will be constantly encouraged to communicate their ideas to both specialists and non specialists audiences. The Erasmus programme will enable students to improve their communications skills, by exchanging informations, problems and solutions.
The specific objectives consist in acquiring the following knowledge and expertise:
1) to understand advanced stereochemistry and its importance on the reactivity of organic compounds;
2) to understand the relationship between structural distortion and reactivity for the different functional groups;
3) to acquire the specific knowledge to understand organic catalysis
4) to acquire the specific knowledge about the main chemical properties of heterocyclic compounds and the main routes to their synthesis;
5) to acquire the specific knowledge to understand the synthetic application of pericyclic reactions;
6) to acquire the specific knowledge to formulate reaction mechanism hypothesis;
7) to acquire the specific knowledge to understand the specific properties of biomolecules.

10611094 | GENERAL AND MOLECULAR PATHOLOGY WITH MEDICAL TERMINOLOGY1st7ITA

Educational objectives

General expected learning outcomes
The General and Molecular Pathology with Medical Terminology course is an essential component of the Pharmaceutical Chemistry and Technology degree program, as it contributes to its educational objectives. This course is designed to equip students with knowledge about the biological basis of pathological manifestations, as well as a fundamental understanding of the pathophysiology of major organ systems. Specifically, the course aims to provide students with a comprehensive understanding of the primary pathogenetic mechanisms that cause homeostatic imbalances and the onset of diseases. The goal the course is to enable students to gain a thorough understanding of various pathological phenomena and the targets of the principal pharmacological treatments. In addition, the course aims to help students develop the necessary scientific language skills characterized by medical terminology to enrich the student's formative background and provide access to expected professional outlets.

Specific expected learning outcomes
1. Knowledge and understanding
By the end of the course, the student will have acquired theoretical knowledge related to cellular and molecular mechanisms underlying the etiopathogenesis of the major human disorders and an appropriate medical and scientific terminology. In addition, the student will have understood the biological processes allowing to the clinical manifestations of the diseases, the targets of the main therapeutic treatments, and the rational basis of the precision medicine.

2. Applying knowledge and understanding
At the end of the course, the student will be able to recognize specific cellular and molecular events underlying different disease processes and identify the main therapeutic targets for these. In addition, the student will possess the skills to link the course content with what he/she has already learned in previous classes and apply the acquired knowledge in scientific and healthcare environments.

3. Making judgements
The active support of the teacher in the classroom will foster and stimulate the student into using a scientifically based methodological approach in both study and future research activities, as well as the ability to make judgments about literature data to be ready to make decisions concerning future professional responsibilities.

4. Communication skills
The student should be able to effectively communicate information, ideas, problems, and solutions to specialized audiences regarding the molecular mechanisms of cellular damage, neoplastic transformation, and the pathophysiological mechanisms of diseases. Furthermore, it is essential for the student to have a strong grasp of specific medical and scientific terminology and to be able to use it appropriately, particularly in the context of the pharmacy profession.

5. Learning skills
The student will be able to integrate the topics covered in the course by consulting the bibliographic materials provided by the teacher and update knowledge and professional skills by consulting specific databases suggested during the class. At the end of the course, the student will have acquired a helpful educational background to undertake more advanced studies, such as those oriented to in-depth professional studies by attending postgraduate courses, graduate schools, PhDs, and joining mobility programs with foreign countries.

1008210 | MOLECULAR BIOLOGY1st8ITA

Educational objectives

General expected learning outcomes
The course provides an overview of modern molecular biology and basic technologies for the manipulation of DNA. The course objective is to acquire knowledge of the molecular mechanisms that allow the maintenance, regulation, and expression of the genome. These skills play an important role in the research and development of new drugs, and applications in biotechnology and biomedicine.

Specific expected learning outcomes
1. Knowledge and understanding
Knowledge of nucleic acids structure and functions.
Knowledge of the molecular mechanisms of DNA replication, repair, transcription and protein synthesis, as well as the regulation of these processes.
Basic knowledge of the main techniques of nucleic acid manipulation, the expression of recombinant proteins and the generation of OGM.

2. Applying knowledge and understanding
Understanding of the molecular processes that control gene expression and regulation, underlying cell growth, division, and differentiation, and which are targets for the action and development of pharmacologically active agents.
Familiarization of students with the experimental approaches used in molecular biology.

3. Making judgements
Students will be invited to ask questions and analyse the topic under discussion so to acquire/perfect their proactive and critical attitude also using skills and knowledge acquired during previous courses.

4. Communication skills
Describe and relate critically the processes studied.

5. Learning skills
Read scientific articles in the field of molecular biologic and gain a critical understanding of their contents.

1008213 | PHYSICAL METHODS IN ORGANIC CHEMISTRY2nd8ITA

Educational objectives

General expected learning outcomes
This course is designed to provide qualitative identification of organic compounds and mixtures, with emphasis on advanced techniques of separation, purification and spectral identification.
The student will experience the most important spectroscopic and analytical techniques used for structure elucidation, which will be useful for his employment in regulatory affairs and healthcare industries.

Specific expected learning outcomes
Understanding and interpretation of UV, FT-IR, proton and carbon-13 NMR spectra.
Structural elucidations of simple organic compounds starting from their raw formula and spectroscopic data. Starting from a mixture of a few known compounds, propose the most suitable chromatographic method based on the acquired knowledge.

1022641 | PHARMACEUTICAL AND TOSSICOLOGICAL CHEMISTRY I2nd9ITA

Educational objectives

General expected learning outcomes
The student will acquire the tools and theoretical-practical strategies for the discovery and design of new active ingredients; in particular, the student will understand the necessary steps from the identification of a molecular prototype to the optimization of a molecule to the realization of a drug.
He or she will, likewise, be able to apply the knowledge acquired in the professional field in the chemical-pharmaceutical industry. In addition, the student will be able to recognize the main chemical structures of drugs belonging to the classes covered in the "syllabus" and will have the ability to design the chemical synthesis of drugs and discuss their properties both qualitatively and quantitatively in terms of structure-activity relationships, physicochemical and pharmaco-toxicological properties.

Specific expected learning outcomes
1. Knowledge and understanding
The student will learn all aspects inherent in the history and molecular development of the classes of drugs with anti-infective activity (antibiotics, antivirals, antifungals, antiparasitics), gastro-intestinal dysfunctions (anti-ulcer, anti-diarrheals, antihistapsi, antacids) and antitumor, with particular reference to the molecular mechanisms of biochemical-biological action, their chemical-pharmaceutical, pharmacological and toxicological properties. Furthermore, the student will know the etiopathogenetic mechanisms that cause the various diseases object of therapeutic treatments with the studied drugs.

2. Applying knowledge and understanding
At the end of the course, the student will be able to identify the different structures of drugs, analyze their biological, pharmacological and toxicological mechanisms of action, and most importantly, be able to adopt strategies for both structural and chemical synthesis design for the eventual development of new chemicals to be transformed into drugs.
Knowledge of the methodologies for the identification and optimization of the parent compounds (lead compounds) will enable the student to be able to approach in academic and/or industrial settings the discovery and/or practical development of new chemical entities, to be able to improve both their pharmacological-therapeutic and toxicological profiles, which are important to achieve market introduction of new drugs. Knowledge of the most prevalent therapeutic problems and pharmaceutical solutions available in the treatment of the diseases discussed in the "syllabus" will make the student proficient and intuitive in the rational choice/consideration of such drugs in the field of human health.

3. Making judgements
The lecturer will stimulate students to develop a logical-critical sense by asking frequent questions (brainstorming) during the lecture with the aim of inducing them to acquire skills in linking (correlative thinking) between the various concepts defined in the "syllabus," mastering the subject matter, but also to consider the study of pharmaceutical and toxicological chemistry I as an integral part and link with other disciplines already studied (anatomy, biology, organic chemistry, molecular biology, microbiology, biochemistry, physiology, pathology) and with others that will follow in future training (pharmaceutical and toxicological chemistry II, pharmacology, pharmacognosy, toxicology, pharmaceutical techniques and legislation, chemical and physical methods in organic chemistry). The instructor will periodically ask students to develop in-depth treatises/theses pertaining to key topics discussed in class, to habituate them to the design of chemical-pharmaceutical scientific research, will submit the students to learning tests to allow for their self-assessment and to have feedback on the teacher's teaching method. At the end of the course, students will be able to make analytical/critical judgment, interpret and correlate complex concepts, and design research inherent in the topics covered for the purpose of expanding scientific, ethical and social knowledge.

4. Communication skills
Through the acquisition of knowledge and understanding, the ability to apply them and to propose a critical judgment on the topics covered, but also through the aid of the related scientific language used by the lecturer during the course and the frequent stimulation of communication of what has been learned in class, the student will be able to communicate with cognitive and linguistic-perceptual depth with figures who are his or her peers and/or who belong to an inherent scientific and social community or of a different cultural background.

5. Learning skills
The student who has acquired the skills described above will be able to undertake future studies in the pharmaceutical field in a more autonomous, self-directed and rapid manner, but also to propose in social and/or work contexts issues useful to the scientific progress of society in the field of human health.

10612243 | GENERAL PHARMACOLOGY AND PHARMACOGNOSY2nd6ITA

Educational objectives

General expected learning outcomes
The course of GENERAL PHARMACOLOGY AND PHARMACOGNOSY aims to provide knowledge to understand the mechanisms of action and pharmacokinetics of drugs, and to provide students with concepts regarding the composition and effects of drugs (biologically active substances of natural origin), their preparations, and the active ingredients contained in them.

The overall objective of the General Pharmacology module is to enable graduates in CTF to acquire competencies related to the fundamental mechanisms that regulate pharmacokinetics and pharmacodynamics, the main factors responsible for the variability of the response, and the main mechanisms and effects of drug interactions. The general objective of the Pharmacognosy lessons is to integrate and complete the knowledge on products of plant origin (drugs, pharmacologically active substances of natural origin, food supplements, etc.). The student, based on the acquired skills, can have a scientific approach to natural products, to be applied in research (drug discovery), in the pharmaceutical industry, in the therapeutic field and/or in the health field. These objectives will be achieved through lessons in classroom.
The overall objective of the Pharmacognosy module is to integrate and complete knowledge on products of plant origin (drugs, biologically active substances of natural origin, dietary supplements, etc.). Based on the acquired competencies, students will be able to have a scientific approach to natural products, which can be applied in research (drug discovery), the pharmaceutical industry, therapeutic field, and/or the health field. These objectives will be achieved through classroom lectures.
Specific expected learning outcomes
1. Knowledge and understanding
Specific objectives of the lessons of General Pharmacology: at the end of the course the student will know and understand the fundamental mechanisms that regulate pharmacokinetics and pharmacodynamics and the main factors responsible for variability in the response to drugs. The assimilated knowledge can be applied for the resolution of various problems concerning the use of drugs and for the understanding of the contents of the Special Pharmacology and Pharmacotherapy course. Students will acquire the ability to critically deal with topics related to current pharmacological issues. These objectives will be achieved through lectures that involve the use of power point, database (es. PubMed) and projections of short movies related to pharmacological issue that can stimulate the critical sense. All these tools will be used to promote interactive discussions in the classroom. Discussions among students will be stimulates in order to improve the ability to communicate with language properties what has been learned.
Specific objectives of the lessons of Pharmacognosy are the acquisition, by the student, of skills related to the different aspects of herbal drugs. In particular: their chemical composition, the pharmacological activity, the practical uses, the possible pharmacokinetic and / or pharmacodynamic interactions with drugs, foods, etc. and any undesired or toxic effects. The student should also acquire ability to exercise critical skills and judgment on the real effectiveness and safety of use of commercial products containing herbal drugs. The applicative autonomy (in the real life) of the concepts learned and the related objectives achieved, will also be made possible by the tools that will be provided to the student during the course, including: scientific literature to refer to, institutional websites, etc., in addition to reference teaching texts.

2. Applying knowledge and understanding
Expected skills: provide the pharmacodynamic (ligand-receptor interaction) and pharmacokinetic (absorption, metabolism, distribution and elimination) basis for understanding the action of drugs, including those of plant origin; address issues related to the development and use of plant-derived drugs. In particular, the student will acquire advanced knowledge of pharmacognosy of medicinal plants and their pharmacologically active principles, therapeutic and toxicological effects, interactions between plant active principles, including those with drugs and foods, and their use in herbal preparations and/or as nutraceuticals.

3. Making judgements
The lessons will be all interactive, in which the teacher will ask the students continuous questions to stimulate them and develop their critical sense. These questions will also serve to evaluate students to make connections, integrating the General Pharmacology and Pharmacognosy in light of the already acquired knowledge, biological type (anatomy human, physiology, biochemistry, microbiology, pathology). The course aims to train future operators who are capable, with total independence, of dispensing and properly advising the public on medicines, self-medication products, and health products.

4. Communication skills
The evaluation of the student's study will be carried out only with an oral exam, which will focus on all the topics of the program, testing the student's communication skills with respect to what they have learned.

5. Learning skills
The student will find the deepening of what he heard in class on the recommended texts and databases (e.g. Pubmed). The texts will remain the reference point of the student who will know where to go to find in detail the notions that are partly forgotten. Moreover, the student will also have the ability to independently undertake more advanced studies such as those aimed at professional specializations by attending post-graduate courses, specialized schools, and research doctorates, also by participating in mobility programs with foreign countries.

GENERAL PHARMACOLOGY2nd3ITA

Educational objectives

General expected learning outcomes
The course of GENERAL PHARMACOLOGY AND PHARMACOGNOSY aims to provide knowledge to understand the mechanisms of action and pharmacokinetics of drugs, and to provide students with concepts regarding the composition and effects of drugs (biologically active substances of natural origin), their preparations, and the active ingredients contained in them.

The overall objective of the General Pharmacology module is to enable graduates in CTF to acquire competencies related to the fundamental mechanisms that regulate pharmacokinetics and pharmacodynamics, the main factors responsible for the variability of the response, and the main mechanisms and effects of drug interactions. The general objective of the Pharmacognosy lessons is to integrate and complete the knowledge on products of plant origin (drugs, pharmacologically active substances of natural origin, food supplements, etc.). The student, based on the acquired skills, can have a scientific approach to natural products, to be applied in research (drug discovery), in the pharmaceutical industry, in the therapeutic field and/or in the health field. These objectives will be achieved through lessons in classroom.
The overall objective of the Pharmacognosy module is to integrate and complete knowledge on products of plant origin (drugs, biologically active substances of natural origin, dietary supplements, etc.). Based on the acquired competencies, students will be able to have a scientific approach to natural products, which can be applied in research (drug discovery), the pharmaceutical industry, therapeutic field, and/or the health field. These objectives will be achieved through classroom lectures.
Specific expected learning outcomes
1. Knowledge and understanding
Specific objectives of the lessons of General Pharmacology: at the end of the course the student will know and understand the fundamental mechanisms that regulate pharmacokinetics and pharmacodynamics and the main factors responsible for variability in the response to drugs. The assimilated knowledge can be applied for the resolution of various problems concerning the use of drugs and for the understanding of the contents of the Special Pharmacology and Pharmacotherapy course. Students will acquire the ability to critically deal with topics related to current pharmacological issues. These objectives will be achieved through lectures that involve the use of power point, database (es. PubMed) and projections of short movies related to pharmacological issue that can stimulate the critical sense. All these tools will be used to promote interactive discussions in the classroom. Discussions among students will be stimulates in order to improve the ability to communicate with language properties what has been learned.
Specific objectives of the lessons of Pharmacognosy are the acquisition, by the student, of skills related to the different aspects of herbal drugs. In particular: their chemical composition, the pharmacological activity, the practical uses, the possible pharmacokinetic and / or pharmacodynamic interactions with drugs, foods, etc. and any undesired or toxic effects. The student should also acquire ability to exercise critical skills and judgment on the real effectiveness and safety of use of commercial products containing herbal drugs. The applicative autonomy (in the real life) of the concepts learned and the related objectives achieved, will also be made possible by the tools that will be provided to the student during the course, including: scientific literature to refer to, institutional websites, etc., in addition to reference teaching texts.

2. Applying knowledge and understanding
Expected skills: provide the pharmacodynamic (ligand-receptor interaction) and pharmacokinetic (absorption, metabolism, distribution and elimination) basis for understanding the action of drugs, including those of plant origin; address issues related to the development and use of plant-derived drugs. In particular, the student will acquire advanced knowledge of pharmacognosy of medicinal plants and their pharmacologically active principles, therapeutic and toxicological effects, interactions between plant active principles, including those with drugs and foods, and their use in herbal preparations and/or as nutraceuticals.

3. Making judgements
The lessons will be all interactive, in which the teacher will ask the students continuous questions to stimulate them and develop their critical sense. These questions will also serve to evaluate students to make connections, integrating the General Pharmacology and Pharmacognosy in light of the already acquired knowledge, biological type (anatomy human, physiology, biochemistry, microbiology, pathology). The course aims to train future operators who are capable, with total independence, of dispensing and properly advising the public on medicines, self-medication products, and health products.

4. Communication skills
The evaluation of the student's study will be carried out only with an oral exam, which will focus on all the topics of the program, testing the student's communication skills with respect to what they have learned.

5. Learning skills
The student will find the deepening of what he heard in class on the recommended texts and databases (e.g. Pubmed). The texts will remain the reference point of the student who will know where to go to find in detail the notions that are partly forgotten. Moreover, the student will also have the ability to independently undertake more advanced studies such as those aimed at professional specializations by attending post-graduate courses, specialized schools, and research doctorates, also by participating in mobility programs with foreign countries.

PHARMACOGNOSY2nd3ITA

Educational objectives

General expected learning outcomes
The course of GENERAL PHARMACOLOGY AND PHARMACOGNOSY aims to provide knowledge to understand the mechanisms of action and pharmacokinetics of drugs, and to provide students with concepts regarding the composition and effects of drugs (biologically active substances of natural origin), their preparations, and the active ingredients contained in them.

The overall objective of the General Pharmacology module is to enable graduates in CTF to acquire competencies related to the fundamental mechanisms that regulate pharmacokinetics and pharmacodynamics, the main factors responsible for the variability of the response, and the main mechanisms and effects of drug interactions. The general objective of the Pharmacognosy lessons is to integrate and complete the knowledge on products of plant origin (drugs, pharmacologically active substances of natural origin, food supplements, etc.). The student, based on the acquired skills, can have a scientific approach to natural products, to be applied in research (drug discovery), in the pharmaceutical industry, in the therapeutic field and/or in the health field. These objectives will be achieved through lessons in classroom.
The overall objective of the Pharmacognosy module is to integrate and complete knowledge on products of plant origin (drugs, biologically active substances of natural origin, dietary supplements, etc.). Based on the acquired competencies, students will be able to have a scientific approach to natural products, which can be applied in research (drug discovery), the pharmaceutical industry, therapeutic field, and/or the health field. These objectives will be achieved through classroom lectures.
Specific expected learning outcomes
1. Knowledge and understanding
Specific objectives of the lessons of General Pharmacology: at the end of the course the student will know and understand the fundamental mechanisms that regulate pharmacokinetics and pharmacodynamics and the main factors responsible for variability in the response to drugs. The assimilated knowledge can be applied for the resolution of various problems concerning the use of drugs and for the understanding of the contents of the Special Pharmacology and Pharmacotherapy course. Students will acquire the ability to critically deal with topics related to current pharmacological issues. These objectives will be achieved through lectures that involve the use of power point, database (es. PubMed) and projections of short movies related to pharmacological issue that can stimulate the critical sense. All these tools will be used to promote interactive discussions in the classroom. Discussions among students will be stimulates in order to improve the ability to communicate with language properties what has been learned.
Specific objectives of the lessons of Pharmacognosy are the acquisition, by the student, of skills related to the different aspects of herbal drugs. In particular: their chemical composition, the pharmacological activity, the practical uses, the possible pharmacokinetic and / or pharmacodynamic interactions with drugs, foods, etc. and any undesired or toxic effects. The student should also acquire ability to exercise critical skills and judgment on the real effectiveness and safety of use of commercial products containing herbal drugs. The applicative autonomy (in the real life) of the concepts learned and the related objectives achieved, will also be made possible by the tools that will be provided to the student during the course, including: scientific literature to refer to, institutional websites, etc., in addition to reference teaching texts.

2. Applying knowledge and understanding
Expected skills: provide the pharmacodynamic (ligand-receptor interaction) and pharmacokinetic (absorption, metabolism, distribution and elimination) basis for understanding the action of drugs, including those of plant origin; address issues related to the development and use of plant-derived drugs. In particular, the student will acquire advanced knowledge of pharmacognosy of medicinal plants and their pharmacologically active principles, therapeutic and toxicological effects, interactions between plant active principles, including those with drugs and foods, and their use in herbal preparations and/or as nutraceuticals.

3. Making judgements
The lessons will be all interactive, in which the teacher will ask the students continuous questions to stimulate them and develop their critical sense. These questions will also serve to evaluate students to make connections, integrating the General Pharmacology and Pharmacognosy in light of the already acquired knowledge, biological type (anatomy human, physiology, biochemistry, microbiology, pathology). The course aims to train future operators who are capable, with total independence, of dispensing and properly advising the public on medicines, self-medication products, and health products.

4. Communication skills
The evaluation of the student's study will be carried out only with an oral exam, which will focus on all the topics of the program, testing the student's communication skills with respect to what they have learned.

5. Learning skills
The student will find the deepening of what he heard in class on the recommended texts and databases (e.g. Pubmed). The texts will remain the reference point of the student who will know where to go to find in detail the notions that are partly forgotten. Moreover, the student will also have the ability to independently undertake more advanced studies such as those aimed at professional specializations by attending post-graduate courses, specialized schools, and research doctorates, also by participating in mobility programs with foreign countries.

1007919 | FOOD CHEMISTRY2nd8ITA

Educational objectives

General expected learning outcomes
The main educational objectives of the Course in Food Chemistry are to provide the student with knowledge regarding the chemical composition of foodstuffs, the influence of the different components on food properties and transformations related to production and conservation processes, and the most common diseases linked to the intake of specific nutrients / foods. The more specific objectives of course concern the acquisition of transversal skills related to the detailed knowledge of: structure and function of macro and micronutrients (carbohydrates, lipids, proteins, vitamins and minerals), fibers and secondary metabolites; transformations of food components during storage and processes; dietetic products intended for individuals in particular physiological conditions or with metabolic disorders.

Specific expected learning outcomes
1. Knowledge and understanding
The knowledge and skills acquired during the Course will be usable by the professional figure in field of work thanks to the acquired critical and judgment skills useful to be able to suggest the use of specific foods for the nutritional intake and for the specific impact on health.

2. Applying knowledge and understanding
The expected learning outcomes, acquired during the course, will therefore allow the future professional figure to correlate and integrate the general aspects concerning the chemical composition of foods with the characteristics of specific food products, thus understanding the correlation between composition and quality and acquiring the ability to process the information on the label; to understand and predict transformations in food as a result of technological and conservation processes; propose dietetic products for pathologies connected with the intake of specific food components.
This knowledge is the basis for operating in a production, control and analysis context and for the design of new products and processes.

3. Making judgements
The course takes place in an alternation of lectures useful to address the concepts of basic theory and classroom presentations prepared by students on current topics concerning food, suitable for stimulating their critical-applicative and communication skills.

4. Communication skills
At the end of the course the student will be able to effectively communicate what has been learned during the course thanks also to the exercise performed with the presentations in the classroom on current topics concerning foodstuffs.

5. Learning skills
The student will be able to continue the study independently, thanks to the acquired skills and the concepts learned also regarding the methods of researching information on the food chemistry sector. During the course will be provided websites, bibliographic references and industry associations, possibly useful for developing collaborative relationships in the world of work. Based on the knowledge acquired, the graduate will have the necessary skills to be able to critically give indication in the field of foods related to health.

4th year

LessonSemesterCFULanguage
1022763 | PHARMACEUTICAL AND TOXICOLOGICAL ANALYTICAL CHEMISTRY III1st10ITA

Educational objectives

General expected learning outcomes
The course of Chemical Pharmaceutical and Toxicological Analysis III aims to provide the theoretical and practical knowledge related to the recognition of compounds of pharmaceutical interest, prevalently with an organic structure, by means of specific chemical assays and instrumental analytical techniques. The student will acquire the ability to understand and apply the methods reported in the latest edition of the European Pharmacopoeia. The course also aims to provide the student with the principles of quality assurance in pharmaceuticals.

Specific expected learning outcomes
1. Knowledge and understanding
At the end of the course, the student will have in-depth knowledge of aspects related to the recognition and evaluation of the purity of compounds in the European Pharmacopoeia, be able to perform both chemical and instrumental recognition assays.

2. Applying knowledge and understanding
At the end of the course the student must be able to recognize an unknown substance using the assays described in the European Pharmacopoeia. It must also be able to purify and determine the purity of the substances present in the European Pharmacopoeia.

3. Making judgements
The practical lessons are interactive and give the opportunity to the student to experiment and realize the recognition and purification of substances, and to determine the purity according to European Pharmacopoeia.

4. Communication skills
The student will be able to give evidence of his learning during practical exercises, during the unknown test scheduled at the end of the exercises and during the oral exam.

5. Learning skills
At the end of the course, the student must be independent in the evaluation of a path of analysis of active ingredients present in pharmaceutical formulations.

10612251 | PHARMACOLOGY AND PHARMACOTHERAPY1st8ITA

Educational objectives

General expected learning outcomes
The aim of the course is to provide a comprehensive preparation to the graduate in CTF regarding the pharmacodynamic and pharmacokinetic profile, adverse effects, pharmacological interactions, and toxicological aspects of the main classes of drugs, as well as their use as a therapeutic tool. Specific skills and technical vocabulary necessary to understand the drug characterization process and to describe their use in therapy will also be provided, as well as skills related to future therapeutic prospects and the rationale for designing new approaches and new drugs that selectively intervene in relevant biological mechanisms in different pathological conditions.

1. Knowledge and understanding
Knowledge acquired expected: Origin and development of drugs; pharmacokinetic and pharmacodynamic properties of the drugs in use; adverse effects and interactions between drugs. Students also have the basic knowledge necessary for the use of drugs in the medical field and the development of drugs in the pharmaceutical industry. The student will know qualitative and quantitative aspects of the receptor drug interaction, principles of pharmacokinetics and pharmacodynamics of the main classes of existing drugs (drugs of the nervous system, analgesic drugs, cardiovascular drugs, sexual and cortical steroids, respiratory drugs, digestive drugs, drugs of inflammation, antimicrobial chemotherapeutics, antituberculous chemotherapeutic agents, antifungals, antiprotozoal, antiviral, anthelmintics, antineoplastic drugs, immune system drugs). The student should also acquire ability to exercise critical skills and judgment on the real effectiveness and safety of use of commercial products containing herbal drugs. The applicative autonomy (in the real life) of the concepts learned and the related objectives achieved, will also be made possible by the tools that will be provided to the student during the course, including: scientific literature to refer to, institutional websites, etc., in addition to reference teaching texts.

2. Applying knowledge and understanding
Expected acquired skills: Addressing issues related to the development and use of drugs. By the end of the course, the student will be familiar with the most important and widespread therapeutic issues and the therapeutic solutions available to doctors to effectively manage and treat various pathologies.

3. Making judgements
The lessons will be all interactive, in which the teacher will ask the students continuous questions to stimulate them and develop their critical sense. These questions will also serve to evaluate students to make connections, integrating the pharmacology and drug therapy considering the already acquired knowledge, biological type (basic pharmacology, anatomy human, physiology, biochemistry, microbiology, pathology). Through these interactive sessions, the student will be able to develop judgment autonomy in the field of pharmacotherapy. The course aims to train future operators who are capable, with total independence, of dispensing and properly advising the public on medicines, self-medication products, and health products.

4. Communication skills
Communication skills will be stimulated and developed throughout the entire course. Students will be exposed to dynamic lessons that include in-class question-and-answer sessions and flipped classroom lessons, in which they will play a part themselves in teaching under the guidance of the teacher. Student progress will be evaluated solely through an oral exam, which will cover all program topics, testing the student's ability to communicate what they have learned.

5. Learning skills
The student will find the deepening of what he heard in class on the recommended texts, institutional websiets and databases (e.g. Pubmed). The texts will remain the reference point of the student who will know where to go to find in detail the notions that are partly forgotten. Moreover, the student will also have the ability to independently undertake more advanced studies such as those aimed at professional specializations by attending post-graduate courses, specialized schools, and research doctorates, also by participating in mobility programs with foreign countries.

1005821 | APPLIED PHARMACEUTICAL CHEMISTRY1st8ITA

Educational objectives

General expected learning outcomes
The teaching of Applied Pharmaceutical Chemistry regards the study of the mechanisms of organic reactions involved in drug metabolism and related to the planning and action of drugs. Pre-formulation studies and accelerated storage tests are introduced in order to calculate the shelf-life of the formulations. Industrial methods to separate, sterilize and freeze-dry an active molecule are also studied.

Specific expected learning outcomes
1. Knowledge and understanding
The student will able to know and understand metabolic processes that drugs understand, valuing the problems of a specific drug, such as toxicity of itself and of its metabolites, as well as any problems of bioavailability and/or stability. The student will acquire knowledge about industrial processes such as filtration, sterilization and freeze-drying.

2. Applying knowledge and understanding
The student will be able to value the problems of a drug and to plane pharmaceutical formulations that allow of overcoming these problems, through chemical modifications of the active. The student will be able to determine the stability of the formulation and to value the deadline of the medicine. Starting to the knowledge of the industrial processes of sterilization, filtration and freeze-drying will be able to choose the best methodologies to apply at a specific drug.

3. Making judgements
The lessons will be interactive, with a continue comparison between teacher and students about the arguments with the aim to stimulate the interest of the students and to increase their critical sense. This discussion will allow calling back arguments already discussed in other teachings, and connected among them.

4. Communication skills
The rating of the student will be made through an oral examination that will have as subject one of the arguments treated during the lessons and applied to a specific drug and this will allow of valuing the making to correlate different aspects and to explain them with adequate scientific language.

5. Learning skills
The student will be able to search in the literature and to study critically the scientific papers related to the teaching. In this way, he will be able to elaborate the possible problems related to the drugs and to overcome them as requested by the industrial world.

10612250 | TOXICOLOGY AND PHARMACOVIGILANCE2nd8ITA

Educational objectives

General expected learning outcomes
The general objective of the Toxicology and Pharmacovigilance course is to provide the student with the basic scientific and regulatory knowledge that will allow him/her to: 1) assess autonomously the risk associated to use or exposure to xenobiotics, particularly drugs; 2) act to minimize the risk, in agreement with regulations and guidelines.

Specific expected learning outcomes
1. Knowledge and understanding
Knowledge of xenobiotic mechanisms of toxicity. Comprehension of the relationship betweem chemical properties and structure and mechanisms of toxicity. Knowledge of the factors influencing the variability in the response to a xenobiotic. Knowledge of toxicokinetics and pharmacokinetics; comprehension of their implications and applications in the pharmaceutical field. Knoweldge on the methods of experimental studies. Comprehension of the risk evaluation process and its pharmaceutical applications. Knowledge of the basis of chemical carcinogenesis and developmental toxicity and the methods used for studying them. Knowledge of pharmacovigilance, both acive and passive.

2. Applying knowledge and understanding
At the end of the course the student should be able to evaluate the risk associated to the use or exposure to drugs and other xenobiotics, also in relations to the characteristics of exposed subjects, of the substance e the way of exposure. The student should be able to propose the measures adequate to minimize the risk, also taking into account the current rules, aprticularly in the pharmaceutical field.

3. Making judgements
During the lessons, the teacher frequently questions the students in order to evaluate the comprehension and the ability to use the knowledge learnt. The students will be confronted many examples of real situations that the students will be asked to evaluate. In the final exam, the student will also have to examine and evaluate concrete cases of toxicological problems in the pharmaceutical field.

4. Communication skills
The student must demonstrate the ability to clearly and concisely express their assessment of the cases presented, using scientifically appropriate vocabulary and correct terminology in the regulatory field.

5. Learning skills
The course aims to provide the formation giving the student the ability of evaluating critically the sources of information widely available, particularly in the web. During the course, the teacher will illustrate the main sources of reliable information, such as databases and sites of institutional organizations.

1022903 | PHARMACEUTICAL TECHNOLOGY AND LEGISLATION2nd10ITA

Educational objectives

General expected learning outcomes
The course on Pharmaceutical Technology and Legislation aims to provide the student with the basic notions regarding pharmaceutical technology, with particular reference to the main conventional pharmaceutical forms. The technological aspect is focused on the realization of medicine both at an industrial level and in the pharmacy.
The course also aims to provide the main information concerning the legislation relating to the marketing authorization of a medicinal product, both at the national and European levels. Within the regulatory framework, attention is also paid to the technical standards that must be followed for the production of a medicinal product.
Knowledge of the regulatory framework also concerns the legislation relating to the marketing and dispensing of medicinal products.
The course will also cover the most relevant aspects relating to digital healthcare, healthcare and management information technology, pharmacoeconomic, and the ethical aspects of the pharmacist, including the regulation of the services provided in the pharmacy.
As regards the practical laboratory exercises, carried out individually, the course aims to provide the student with the basic knowledge for the preparation of masterful and medicinal formulas, to carry out the checks required by the Official Pharmacopoeia, to evaluate the correct compilation of the medical prescription, to know and apply the rules connected to the act of dispensing, including the compilation of the label and the assessment of the risks related to the preparation.

Specific expected learning outcomes
1. Knowledge and understanding
At the end of the course, the student will have acquired the basic knowledge of pharmaceutical technology regarding the formulation, preparation, and control of the main conventional pharmaceutical forms.
The student will also have learned the basics of Italian and European legislation regarding the marketing of medicines and the main regulations concerning the dispensing of medicines in pharmacies.

2. Applying knowledge and understanding
At the end of the course, the student will have learned the basic knowledge of pharmaceutical technology that will allow him to monitor and control the various phases of the industrial production of medicines, follow the bureaucratic process to obtain the AIC according to the current regulatory framework.
The student will be able to set up the main pharmaceutical forms, taking into account the regulatory framework and safety. You will be able to perform the calculations for the correct preparation of a masterful preparation after checking the formalisms of the medical prescription.
You will have acquired the knowledge to evaluate the correctness of a medical prescription and will be able to recognize the dispensing regime in accordance with current legislation.

3. Making judgements
The lessons, also carried out in an interactive way, often refer to contemporary problems in the pharmaceutical field. The laboratory exercises, carried out individually, and the numerical exercises, turn out to be all activities that, in a synergistic way, help to stimulate her critical skills in the student. The student is thus able to evaluate, having as a prerequisite a good basic preparation, the technological and regulatory aspects relating to the industrial preparation of medicines and also to their preparation as masterful preparations.

4. Communication skills
During the lessons, the teacher will solicit debate and comparison to stimulate in the student good reasoning and communication skills that will be useful in the workplace, both in the case of inclusion in work groups in which he will have to deal with other colleagues and in the case he is entrusted with the task of controlling company activities carried out by others which must be coordinated by him.
Good communication, together with good technical knowledge, will also be essential in the case of practicing the profession of pharmacist in which contact with the public plays a fundamental role in terms of the possibility of providing patients with highly professional advice and information (e.g. how to use the medicine correctly, how to avoid interactions with other active ingredients).

5. Learning skills
The student, also thanks to the help of the recommended texts and websites, will be able to enter the world of work, both in the industrial sector and in the pharmacy sector. This will be possible because the student will have become aware, during the course of the lessons and during the preparation for the exam, of how essential continuous updating is for professional purposes, both from the point of view of new technologies and from a regulatory point of view, a reality which are always evolving.

1022642 | MEDICINAL AND TOXICOLOGICAL CHEMISTRY II2nd9ITA

Educational objectives

General expected learning outcomes
The course of Medicinal Chemistry and Toxicology 2 aims to teach the student, in different therapeutic categories, the drugs that represent milestones in the treatment of related diseases, the drug discovery process that led to their identification, the relationships between chemical structure and biological activity, chemical synthesis, molecular mechanism, pharmacological and toxicological effects, the main side effects, the possibility of combined treatments, social and economic implications.

Specific expected learning outcomes
1. Knowledge and understanding
The student will know all the aforementioned aspects concerning nervous system drugs, both depressive (neuroleptic, anti-anxiety, hypnotics-sedatives, anticonvulsants, anti-Parkinson’s) and stimulants (analectics, antidepressants), narcotic and non-narcotic analgesic drugs, cardiovascular drugs (antiarrhythmics, vasodilators of the coronary, antihypertensive, diuretic, hypolipidemic agents), drugs of the autonomous nervous system (adrenergic and cholinergic), sexual and cortical steroids.

2. Applying knowledge and understanding
At the end of the course the student will recognize a drug belonging to a mentioned category, from another not belonging to the same therapeutic area. He will know which are the most relevant structure-activity relationships in a serie of drugs, and which are the points of the drug that can be chemically modified and which ones can not be altered otherwise the loss of biological activity. He will know the main organic reactions that lead to the synthesis of various drugs. He will know what are the chemical requirements for a molecule to be ligand of a particular receptor, enzyme or ion channel that represents the target of known drugs. He will know the most important and widespread therapeutic problems and therapeutic solutions available to cope and effectively treat the various diseases.

3. Making judgements
The lessons will be all interactive, in which the teacher will ask the students continuous questions to stimulate them and develop their critical sense. These questions will also serve to evaluate and solicit students to make connections with everything studied so far, avoiding to consider the study of the subject a study in itself but integrating the pharmaceutical chemistry in light of the knowledge already acquired, both chemical (inorganic, organic, biochemical chemistry) than biological (anatomy, physiology, pathology, pharmacology, pharmacognosy, toxicology).

4. Communication skills
The evaluation of the student's study will be carried out only with an oral exam, which will focus on all the topics of the program, testing the student's communication skills with respect to what he has learned.

5. Learning skills
The student will find the deepening of what he heard in class on the recommended texts. This research work will serve to enable him to rediscover the topics dealt in the future, when the memories of the concepts taught in the classroom will be blurred. The texts will remain the reference point of the student who will know where to go to find in detail the notions that are partly forgotten.

10612245 | INDUSTRIAL MANUFACTURING AND DRUG DELIVERY2nd12ITA

Educational objectives

General expected learning outcomes
The Industrial Manufacturing of Medicines course aims to provide the knowledge related to the marketing procedure (AIC), to the industrial plant engineering, to the production processes of drugs, to the Good Manufacturing Practice (GMP) and Standards. At the same time the students will acquire the competences of the pharmaceutical technologies used in the industrial production and packaging of medicines. The course will also allow the students to be informed about the regulations that are needed, and later applied, for an appropriate planning and validation for the industrial production of medicines. During specific moments of discussion and deeper insight the students will have the opportunity to contact people that exert their professional activity in pharmaceutical companies.
Industrial Manufacturing of Medicines is an interdisciplinary course that has an applicative approach which will allow, after the final degree (laurea specialistica), to enter the working world because he/she will be able to face, analyze and evaluate the various problems related to the industrial processes that are needed for medicine marketing.

Specific expected learning outcomes
1. Knowledge and understanding
Regulation, technologies, processes, and plant engineering knowledge required to operate with high qualification in the manufacturing industry of traditional, innovative, and biotechnological medicines will be acquired.

2. Applying knowledge and understanding
At the end of the course the student will be able to apply the information given during the lectures that will face the specific topics related to the chemical-pharmaceutical industry, both from a technical point of view as well as in accordance with current regulations.
The student will be able to follow the various phases of drug production for the different dosage forms. At the same time, the acquired preparation, will allow him/her to face all the steps and problems related to formulation, regulation, safety, and validation.

3. Making judgements
The “classical” lectures will include discussion and assessment method moments, together with programmed interactions with people directly involved in pharmaceutical companies, will allow the students to organize and follow a specific project. Taking into consideration one of the topics that were faced during the course they will be able to write (singularly or as a team) a report that can demonstrate their autonomous ability to evaluate the technological, regulatory and safety issues related to the manufacturing of the various dosage forms.
The students will be divided in small groups and then it will be requested to apply, according to a more practical approach, the information acquired during the first part of the lesson. For a deeper insight, experts in the specific fields faced during the lessons will be invited.

4. Communication skills
During the course, several moments will be devoted to debates, discussions, and roundtables under the professor’s supervision; in this sense specific selected topics will be assigned to the students. This activity, that will be carried out both individually and as small groups, will allow to evaluate the communication skills of the students with respect to the acquired information. These sessions will be important to develop the ability to critically evaluate technological, regulatory and safety issues related to the manufacturing of the various dosage forms. In these occasions the students will also develop their ability to properly report on the selected topics in front of the professor and their colleagues (peer assessment).

5. Learning skills
Both theoretical and practical information that will be given during the course is also intended to develop the personal ability of an autonomous and independent learning (continuous education). This will allow the students to critically evaluate the medicine production and validation processes, and to appropriately understand, and correctly apply, the current regulations. Furthermore, the preparation acquired during the course will allow the students to keep his/her information and skills always updated in the field of industrial pharmaceutical production: a world which is in continuous and rapid evolution.

INDUSTRIAL DRUG MANUFACTURING2nd6ITA

Educational objectives

INDUSTRIAL DRUG MANUFACTURING
General expected learning outcomes
The Industrial Manufacturing of Medicines course aims to provide the knowledge related to the marketing procedure (AIC), to the industrial plant engineering, to the production processes of drugs, to the Good Manufacturing Practice (GMP) and Standards. At the same time the students will acquire the competences of the pharmaceutical technologies used in the industrial production and packaging of medicines. The course will also allow the students to be informed about the regulations that are needed, and later applied, for an appropriate planning and validation for the industrial production of medicines. During specific moments of discussion and deeper insight the students will have the opportunity to contact people that exert their professional activity in pharmaceutical companies.
Industrial Manufacturing of Medicines is an interdisciplinary course that has an applicative approach which will allow, after the final degree (laurea specialistica), to enter the working world because he/she will be able to face, analyze and evaluate the various problems related to the industrial processes that are needed for medicine marketing.

Specific expected learning outcomes
1. Knowledge and understanding
Regulation, technologies, processes, and plant engineering knowledge required to operate with high qualification in the manufacturing industry of traditional, innovative, and biotechnological medicines will be acquired.

2. Applying knowledge and understanding
At the end of the course the student will be able to apply the information given during the lectures that will face the specific topics related to the chemical-pharmaceutical industry, both from a technical point of view as well as in accordance with current regulations.
The student will be able to follow the various phases of drug production for the different dosage forms. At the same time, the acquired preparation, will allow him/her to face all the steps and problems related to formulation, regulation, safety, and validation.

3. Making judgements
The “classical” lectures will include discussion and assessment method moments, together with programmed interactions with people directly involved in pharmaceutical companies, will allow the students to organize and follow a specific project. Taking into consideration one of the topics that were faced during the course they will be able to write (singularly or as a team) a report that can demonstrate their autonomous ability to evaluate the technological, regulatory and safety issues related to the manufacturing of the various dosage forms.
The students will be divided in small groups and then it will be requested to apply, according to a more practical approach, the information acquired during the first part of the lesson. For a deeper insight, experts in the specific fields faced during the lessons will be invited.

4. Communication skills
During the course, several moments will be devoted to debates, discussions, and roundtables under the professor’s supervision; in this sense specific selected topics will be assigned to the students. This activity, that will be carried out both individually and as small groups, will allow to evaluate the communication skills of the students with respect to the acquired information. These sessions will be important to develop the ability to critically evaluate technological, regulatory and safety issues related to the manufacturing of the various dosage forms. In these occasions the students will also develop their ability to properly report on the selected topics in front of the professor and their colleagues (peer assessment).

5. Learning skills
Both theoretical and practical information that will be given during the course is also intended to develop the personal ability of an autonomous and independent learning (continuous education). This will allow the students to critically evaluate the medicine production and validation processes, and to appropriately understand, and correctly apply, the current regulations. Furthermore, the preparation acquired during the course will allow the students to keep his/her information and skills always updated in the field of industrial pharmaceutical production: a world which is in continuous and rapid evolution.

DRUG DELIVERY AND DRUG TARGETING
General expected learning outcomes
The teaching of Drug Targeting and Delivery provides to the students the main methods to optimize the drug efficiency, starting from the physical-chemical characteristics of the active molecule and the request administration ways. The teaching will present all the most important drug delivery systems, suitable to obtain the therapeutic effect of a specific dug, minimizing its toxicity and increasing the targeting. The teaching tries to increase the interest of the student towards a multidisciplinary research work, employing the knowledge acquired in the previous years of the degree course.

Specific expected learning outcomes
1. Knowledge and understanding
The student will able to know and understand physical-chemical characteristics of the drugs and the problems related to their delivery such as bioavailability and stability. The student will be able to plain smart drug delivery systems able to target the drug, to the aim of minimizing toxicity and increase the activity.

2. Applying knowledge and understanding
The student will be able to value the problems of a drug and to plane innovative pharmaceutical formulations that allow of overcoming these problems. The student will be able to to examine critically the different drug delivery systems in order to choose the most suitable for the specific drug and administration route.

3. Making judgements
The lessons will be interactive, with a continue comparison between teacher and students about the arguments, with the aim to stimulate the interest of the students and to increase their critical sense. This discussion will allow calling back arguments already discussed in other teachings, and connected among them.

4. Communication skills
The rating of the student will be made through an oral examination that will have as subject one of the arguments treated during the lessons. The student will search in the literature a recent research paper on the argument, and will present critically the results with a Power Point presentation.

5. Learning skills
The student will be able to search in the literature and to study critically the scientific papers related to the arguments of the teaching. In this way, he will be able to plan innovative formulations in order to increase the efficacy of old drugs by new technological methodologies, as requested by the industrial world.

DRUG DELIVERY AND DRUG TARGETING2nd6ITA

Educational objectives

General expected learning outcomes
The Industrial Manufacturing of Medicines course aims to provide the knowledge related to the marketing procedure (AIC), to the industrial plant engineering, to the production processes of drugs, to the Good Manufacturing Practice (GMP) and Standards. At the same time the students will acquire the competences of the pharmaceutical technologies used in the industrial production and packaging of medicines. The course will also allow the students to be informed about the regulations that are needed, and later applied, for an appropriate planning and validation for the industrial production of medicines. During specific moments of discussion and deeper insight the students will have the opportunity to contact people that exert their professional activity in pharmaceutical companies.
Industrial Manufacturing of Medicines is an interdisciplinary course that has an applicative approach which will allow, after the final degree (laurea specialistica), to enter the working world because he/she will be able to face, analyze and evaluate the various problems related to the industrial processes that are needed for medicine marketing.

Specific expected learning outcomes
1. Knowledge and understanding
Regulation, technologies, processes, and plant engineering knowledge required to operate with high qualification in the manufacturing industry of traditional, innovative, and biotechnological medicines will be acquired.

2. Applying knowledge and understanding
At the end of the course the student will be able to apply the information given during the lectures that will face the specific topics related to the chemical-pharmaceutical industry, both from a technical point of view as well as in accordance with current regulations.
The student will be able to follow the various phases of drug production for the different dosage forms. At the same time, the acquired preparation, will allow him/her to face all the steps and problems related to formulation, regulation, safety, and validation.

3. Making judgements
The “classical” lectures will include discussion and assessment method moments, together with programmed interactions with people directly involved in pharmaceutical companies, will allow the students to organize and follow a specific project. Taking into consideration one of the topics that were faced during the course they will be able to write (singularly or as a team) a report that can demonstrate their autonomous ability to evaluate the technological, regulatory and safety issues related to the manufacturing of the various dosage forms.
The students will be divided in small groups and then it will be requested to apply, according to a more practical approach, the information acquired during the first part of the lesson. For a deeper insight, experts in the specific fields faced during the lessons will be invited.

4. Communication skills
During the course, several moments will be devoted to debates, discussions, and roundtables under the professor’s supervision; in this sense specific selected topics will be assigned to the students. This activity, that will be carried out both individually and as small groups, will allow to evaluate the communication skills of the students with respect to the acquired information. These sessions will be important to develop the ability to critically evaluate technological, regulatory and safety issues related to the manufacturing of the various dosage forms. In these occasions the students will also develop their ability to properly report on the selected topics in front of the professor and their colleagues (peer assessment).

5. Learning skills
Both theoretical and practical information that will be given during the course is also intended to develop the personal ability of an autonomous and independent learning (continuous education). This will allow the students to critically evaluate the medicine production and validation processes, and to appropriately understand, and correctly apply, the current regulations. Furthermore, the preparation acquired during the course will allow the students to keep his/her information and skills always updated in the field of industrial pharmaceutical production: a world which is in continuous and rapid evolution.

5th year

LessonSemesterCFULanguage
AAF2380 | PRACTICAL EVALUATIVE INTERNSHIP1st30ITA
AAF2381 | FINAL EXAMINATION2nd30ITA
Complementary module
Insight activities

Optional groups

The student must acquire 6 CFU from the following exams
LessonYearSemesterCFULanguage
10612252 | RADIOPHARMACEUTICAL CHEMISTRY5th1st6ITA

Educational objectives

General expected learning outcomes
The Chemistry of Radiopharmaceuticals course aims to teach the student the various types of radiopharmaceuticals most commonly used in the field of nuclear medicine for both diagnostic and therapeutic purposes. The further aim of the course includes teaching the various methods of synthesis of a radionuclide, the creation of a radiopharmaceutical through different labeling processes, learning the mechanism of bio-distribution and localization of the radiopharmaceutical in the body, the techniques used for the detection of the radiations emitted during the various radioactive decays, the interactions between radiations and organic molecules and a general knowledge of the legislative landscape linked to the commercial distribution of radiopharmaceuticals. Finally, a further objective involves the description and use of latest generation radiopharmaceuticals for the treatment of various pathologies.

Specific expected learning outcomes
1. Knowledge and understanding
The student will be aware of all the aspects described above regarding the production (synthesis and labeling methods) of the main radiopharmaceuticals used for the osteoarticular system, for the pulmonary system, for the gastrointestinal system, for the urinary system and for the central nervous system.

2. Applying knowledge and understanding
At the end of the course the student will have knowledge of the importance of using a radiopharmaceutical in nuclear medicine. You will be able to recognize the mechanisms that link the detection system of a radiation emitted by a radiopharmaceutical with the identification of an ongoing pathological process either of inflammatory origin or inherent to the presence of a tumor form. You will be able to discriminate between the radiopharmaceuticals on the market, those to be used for diagnostic and/or therapeutic purposes. You will know the benefits and possible risks of using a radiopharmaceutical.

3. Making judgements
The lessons will all be frontal and interactive, during which the students will be stimulated to make connections with the various parts of the program carried out and with the notions previously acquired in the course of other teachings of the previous years. This in order to collectively involve the class in an active and critical way throughout the duration of the course.

4. Communication skills
The assessment of the student's learned notions will be carried out through a written test and possibly an oral test which will focus on all the topics of the program, testing the student's communication skills with respect to what she has learned.

5. Learning skills
The student will be able to independently continue the study of the subject thanks to a series of handouts provided by the teacher and recommended textbooks for further study. This will allow the student to always have the material available on which to review the topics covered.

10616516 | STOICHIOMETRY5th1st6ITA

Educational objectives

General expected learning outcomes
The course aims to illustrate the principles of stoichiometry, which studies the weight ratios in chemical reactions, and provide the student with the skills necessary to solve stoichiometry problems/calculations preparatory to exercises and experimental activities in the laboratory. Upon completion of the course the student will have acquired basic skills relating to the use of calculation tools in the various problems of General and Inorganic Chemistry.

Specific expected learning outcomes
1. Knowledge and understanding
The student will acquire knowledge relating to: nomenclature of the main classes of inorganic compounds; chemical reactions and redox processes; calculation of the reaction yield; solutions and concentration units, mixing and dilutions; colligative properties; volumetric analyses; the gaseous state; law of mass action; homogeneous and heterogeneous equilibria; acid-base reactions and titrations.

2. Applying knowledge and understanding
At the end of the course the student will be able to balance chemical reactions; identify defective reagents; convert units of different concentrations; calculate the volumes of solvent required in mixing and dilutions; calculate the values of constants relating to homogeneous and heterogeneous equilibrium equilibria; calculate the pH of solutions of strong/weak and polyprotic acids/bases and their mixtures.

3. Making judgements
The lessons will be interactive and students will be encouraged to make critical connections between the various topics; in this way they will develop the ability to apply the notions and methods acquired to practical cases that can be used in chemical and laboratory courses in subsequent years.

4. Communication skills
Particular attention will be paid to ensure that the student acquires and uses: correct chemical terminology; a clear, precise and concise language based on the scientific skills learned; an effective ability to understand and communicate the course contents in written and oral forms.

5. Learning skills
The study of the topics covered in class will be based on material and texts made available to the student on the e-learning platform. The study method and concepts acquired in the course provide solid foundations for learning basic and specialized chemical subjects.

10612264 | INNOVATIVE AND BIOTECHNOLOGICAL DRUGS WITH ANTICANCER ACTIVITY5th1st6ITA

Educational objectives

General expected learning outcomes
The course in INNOVATIVE AND BIOTECHNOLOGICAL DRUGS WITH ANTICANCER ACTIVITY aims to initiate the student, in a multidisciplinary study, in the approach to very recent and current science, which has made great strides in the last twenty years in various areas of research: epigenetics. Brief topics in genetics, biology, biochemistry, pharmacology, and toxicology will be covered as indispensable notions for study, although the main thrust of the course should be chemical-pharmaceutical, i.e., the validation of various epigenetic targets for various diseases, foremost among them cancer, and the rational design and latest methods of identifying compounds that interfere with or modulate these targets. Advanced molecular biology and biochemistry techniques for the production of biotechnological drugs will be specifically illustrated.

Specific expected learning outcomes
1. Knowledge and Understanding
The student will be familiar with all chemical-pharmaceutical aspects of epigenetic ligands with special emphasis on those that are approved or in late-stage clinical trials. Fundamental notions will cover catalytic mechanisms and biological implications of targets involved in disease development. In the section on biotech drugs with antitumor activity, she/he will be introduced to the use of advanced techniques for biotech drug discovery and production.

2. Applying knowledge and understanding
At the end of the course, the student will know how to recognize, when possible, known pharmacophoric patterns useful for designing new ligands for a particular epigenetic target. She/he will know the most relevant structure-activity relationships relative to these compounds, and which points on the drug can be chemically altered and/or which cannot be altered on pain of loss of biological activity. She/he will know the effects of these compounds on altered signalling pathways leading to disease, with reference to apoptotic, necrotic, and autophagic pathways. She/he will know the most important and widespread therapeutic problems and available therapeutic solutions in the context of epigenetic therapy. The application of advanced biotechnology techniques will enable the student to understand the importance of the evolution of personalized and target-specific anticancer therapies.

3. Making judgements
The lectures will be all interactive, in which the lecturer will ask students continuous questions to stimulate them and develop their critical sense. These questions will also serve to evaluate and prompt students to make connections with all that they have studied so far, avoiding considering the study of the subject an end in itself but integrating medicinal chemistry in the light of the knowledge they have already acquired, both chemical (organic chemistry, biochemistry) and biological (pathology, pharmacology, pharmacognosy, toxicology).

4. Communication skills
Evaluation of the student's study will be carried out solely by an oral test, which will cover the topics of the program, testing the student's ability to communicate what he or she has learned. Much appreciated in recent years by the students is the PowerPoint mode, in which the lecturer assigns them a scientific paper in epigenetics and they have to prepare and describe in a ppt presentation the assumptions, rationale and results of the same, also with a critical judgment on the work of the authors and the construction/conduct of the paper. A further question will concern the part of biotechnological drugs.

5. Learning skills
The student will find the in-depth study of what was heard in class on scientific reviews suggested by the teachers.

INNOVATIVE DRUGS WITH ANTICANCER ACTIVITY5th1st3ITA

Educational objectives

General expected learning outcomes
The course in INNOVATIVE AND BIOTECHNOLOGICAL DRUGS WITH ANTICANCER ACTIVITY aims to initiate the student, in a multidisciplinary study, in the approach to very recent and current science, which has made great strides in the last twenty years in various areas of research: epigenetics. Brief topics in genetics, biology, biochemistry, pharmacology, and toxicology will be covered as indispensable notions for study, although the main thrust of the course should be chemical-pharmaceutical, i.e., the validation of various epigenetic targets for various diseases, foremost among them cancer, and the rational design and latest methods of identifying compounds that interfere with or modulate these targets. Advanced molecular biology and biochemistry techniques for the production of biotechnological drugs will be specifically illustrated.

Specific expected learning outcomes
1. Knowledge and Understanding
The student will be familiar with all chemical-pharmaceutical aspects of epigenetic ligands with special emphasis on those that are approved or in late-stage clinical trials. Fundamental notions will cover catalytic mechanisms and biological implications of targets involved in disease development. In the section on biotech drugs with antitumor activity, she/he will be introduced to the use of advanced techniques for biotech drug discovery and production.

2. Applying knowledge and understanding
At the end of the course, the student will know how to recognize, when possible, known pharmacophoric patterns useful for designing new ligands for a particular epigenetic target. She/he will know the most relevant structure-activity relationships relative to these compounds, and which points on the drug can be chemically altered and/or which cannot be altered on pain of loss of biological activity. She/he will know the effects of these compounds on altered signalling pathways leading to disease, with reference to apoptotic, necrotic, and autophagic pathways. She/he will know the most important and widespread therapeutic problems and available therapeutic solutions in the context of epigenetic therapy. The application of advanced biotechnology techniques will enable the student to understand the importance of the evolution of personalized and target-specific anticancer therapies.

3. Making judgements
The lectures will be all interactive, in which the lecturer will ask students continuous questions to stimulate them and develop their critical sense. These questions will also serve to evaluate and prompt students to make connections with all that they have studied so far, avoiding considering the study of the subject an end in itself but integrating medicinal chemistry in the light of the knowledge they have already acquired, both chemical (organic chemistry, biochemistry) and biological (pathology, pharmacology, pharmacognosy, toxicology).

4. Communication skills
Evaluation of the student's study will be carried out solely by an oral test, which will cover the topics of the program, testing the student's ability to communicate what he or she has learned. Much appreciated in recent years by the students is the PowerPoint mode, in which the lecturer assigns them a scientific paper in epigenetics and they have to prepare and describe in a ppt presentation the assumptions, rationale and results of the same, also with a critical judgment on the work of the authors and the construction/conduct of the paper. A further question will concern the part of biotechnological drugs.

5. Learning skills
The student will find the in-depth study of what was heard in class on scientific reviews suggested by the teachers.

BIOTECHNOLOGICAL DRUGS WITH ANTICANCER ACTIVITY5th1st3ITA

Educational objectives

General expected learning outcomes
The course in INNOVATIVE AND BIOTECHNOLOGICAL DRUGS WITH ANTICANCER ACTIVITY aims to initiate the student, in a multidisciplinary study, in the approach to very recent and current science, which has made great strides in the last twenty years in various areas of research: epigenetics. Brief topics in genetics, biology, biochemistry, pharmacology, and toxicology will be covered as indispensable notions for study, although the main thrust of the course should be chemical-pharmaceutical, i.e., the validation of various epigenetic targets for various diseases, foremost among them cancer, and the rational design and latest methods of identifying compounds that interfere with or modulate these targets. Advanced molecular biology and biochemistry techniques for the production of biotechnological drugs will be specifically illustrated.

Specific expected learning outcomes
1. Knowledge and Understanding
The student will be familiar with all chemical-pharmaceutical aspects of epigenetic ligands with special emphasis on those that are approved or in late-stage clinical trials. Fundamental notions will cover catalytic mechanisms and biological implications of targets involved in disease development. In the section on biotech drugs with antitumor activity, she/he will be introduced to the use of advanced techniques for biotech drug discovery and production.

2. Applying knowledge and understanding
At the end of the course, the student will know how to recognize, when possible, known pharmacophoric patterns useful for designing new ligands for a particular epigenetic target. She/he will know the most relevant structure-activity relationships relative to these compounds, and which points on the drug can be chemically altered and/or which cannot be altered on pain of loss of biological activity. She/he will know the effects of these compounds on altered signalling pathways leading to disease, with reference to apoptotic, necrotic, and autophagic pathways. She/he will know the most important and widespread therapeutic problems and available therapeutic solutions in the context of epigenetic therapy. The application of advanced biotechnology techniques will enable the student to understand the importance of the evolution of personalized and target-specific anticancer therapies.

3. Making judgements
The lectures will be all interactive, in which the lecturer will ask students continuous questions to stimulate them and develop their critical sense. These questions will also serve to evaluate and prompt students to make connections with all that they have studied so far, avoiding considering the study of the subject an end in itself but integrating medicinal chemistry in the light of the knowledge they have already acquired, both chemical (organic chemistry, biochemistry) and biological (pathology, pharmacology, pharmacognosy, toxicology).

4. Communication skills
Evaluation of the student's study will be carried out solely by an oral test, which will cover the topics of the program, testing the student's ability to communicate what he or she has learned. Much appreciated in recent years by the students is the PowerPoint mode, in which the lecturer assigns them a scientific paper in epigenetics and they have to prepare and describe in a ppt presentation the assumptions, rationale and results of the same, also with a critical judgment on the work of the authors and the construction/conduct of the paper. A further question will concern the part of biotechnological drugs.

5. Learning skills
The student will find the in-depth study of what was heard in class on scientific reviews suggested by the teachers.

10612248 | ANALYSIS OF DRUGS AND DRUG METABOLITES IN BIOLOGICAL FLUIDS5th1st6ITA

Educational objectives

General expected learning outcomes
The aim of the teaching Analisi dei farmaci e dei metaboliti nei fluidi biologici is to ensure knowledge of the main aspects of the methods that can be used for the qualitative-quantitative analysis and pharmacological characterization of drugs and their metabolites, both in biological fluids and in “in vitro” model systems, from sample selection operations to processing, interpretation and transmission of results.

Specific expected learning outcomes
In this teaching, the students will have to acquire the following detailed skills according to Dublin descriptors:

1. Knowledge and understanding
Students acquire ability to discriminate the specific purposes of the different types of analytical investigations in biological fluids. Knowledge of the characteristics, differences and specificity of the various biological matrices. Definition of criteria for the correct selection, design, validation and application of complete analytical procedures for the identification and quantitative determination of drugs and their metabolites in biological matrices.

2. Applying knowledge and understanding
The student will acquire the ability to correctly frame an analytical problem, with particular regard to the research of drugs and metabolites in biological fluids of different kind and nature, and the ability to find information from the study of the reference scientific bibliography.

3. Making judgements
One of the fundamental objectives of teaching is constituted by critical learning. It is pursued systematically through the continuous interaction between teacher and students.

4. Communication skills
Students acquire the ability to communicate knowledge, problems and solutions related to the analysis of drugs and metabolites in biological fluids. They are also able to expose assessments and motivations in a clear and understandable way to specialists and non-specialists.

5. Learning skills
The student will be able to independently learn all the analytical techniques thanks to the availability of texts and handouts and also thanks to the consultation of scientific articles related to the topics of the course, which are published in indexed international scientific journals.

10612249 | BIOCHEMICAL AND BIOTECHNOLOGICAL APPLICATIONS5th1st6ITA

Educational objectives

General expected learning outcomes
The aim of the Biochemical and Biotechnological Applications course is to allow the student an in-depth knowledge of biochemical and biotechnological techniques from both a theoretical and practical perspective. The final aim is to prepare him/her to make use of these techniques to develop, in a creative and inventive way, new investigation strategies as well as new diagnostic and therapeutic approaches to pathologies.

Specific expected learning outcomes
1. Knowledge and understanding
The student will gain up-to-date knowledge in the field of Biotechnological Techniques (Biochemistry and Molecular Biology) and relevant research application. In particular, he/she will deepen his/her knowledge of macromolecules separation and detection techniques (e.g. Southern, Northern and Western blotting; Immuno-precipitation; Microarrays; Biosensors); genetic manipulation techniques (e.g. Cloning and Expression vectors in prokaryotes and eukaryotes; Mutagenesis; PCR and Real-Time PCR) and relevant applications in research, diagnostics and therapy. For these techniques, he/she will study both the theoretical background and the procedural approach /experimental design applied to an in vitro or in vivo experiment . He/She will also study the recent applications of Biotechnology in different research fields, such as design and production of: recombinant vaccines; humanized antibodies: anticancer drugs; use of enzymes in diagnostics and molecular therapy; genetically modified organisms (GMOs); RNA and SiRNA interfering techniques; Genome Editing via Crispr/CAS system).

2. Applying knowledge and understanding
The student will be able to approach the research in the biochemical/pharmacological field using the latest biotechnology methodologies. He/she will be able to identify the most appropriate and profitable research strategy to best address the design of novel diagnostic methods or new-generation therapeutic approaches, or to improve existing therapies. He/she will be able to spot critical points as well as those that can be implemented. Altogether, He/she will know the most advanced therapeutic strategies and solutions deriving from the application and use of biotechnological techniques to the treatment of specific pathologies.

3. Making judgements
The course will consist of interactive lessons held in a classroom. The teacher will explain the general concepts and emphasize important points using an interactive approach based on class discussion and questions aimed at developing a problem-solving attitude, both during the lecture and homework. Students will also be invited to ask questions and analyse the topic under discussion so to acquire/perfect their proactive and critical attitude also using skills and knowledge acquired during previous courses.

4. Communication skills
The exam includes an oral interview and a power point presentation with a dissertation examining one or more topics of the course program, with specific focus on Biotechnologies. This kind of exam will allow evaluating the student's communication skills in relation to what he/she learned during the course.

5. Learning skills
The student will be able to deepen the topics covered during the course by use of the recommended texts. These textbooks will remain as a future reference for the student. The student will also develop the learning ability that will allow He/She to update his/her knowledge through the consultation of updated scientific bibliography.

10612246 | PRECISION ONCOLOGY5th1st6ITA

Educational objectives

General expected learning outcomes
The course is aimed to provide knowledge concerning the main molecular mechanisms implied in the pathogenesis of cancer, in order to give the theoretical basis for the development of new diagnostic, prognostic and therapeutic procedures in oncology.

Specific expected learning outcomes
1. Knowledge and understanding
During the course the student will acquire knowledge about causes and pathogenic mechanisms of cancer, specifically referring to genetic and epigenetic alterations, altered pathways in cancer, therapeutic targets and molecular mechanisms of drug resistance in cancer therapy. This knowledge will be applied in the development of new targeted therapies in cancer. A further objective of the course is to equip the figure of the graduate in CTF with the basic theoretical tools for the understanding of clinical trials in oncology, of the research methodology, of the national legislation that governs its management .

2. Applying knowledge and understanding
The knowledge of the molecular mechanisms involved in cancer progression will make the student:
-able to link the alterations at the molecular level with the identification of new therapeutic targets
- possessing the appropriate skills to carry out both activities within the NHS's local pharmaceutical services and research activities;
- capable of independent judgment with reference to the evaluation, interpretation and reprocessing of literature data;
- able to elaborate in a critical and autonomous way original ideas in a biomedical research context;
- able to communicate the acquired information to specialists and non-specialists in the field of oncology.

3. Making judgements
The student will be able to independently collect and interpret data derived from scientific studies in oncology by reading scientific articles in English as well as to communicate information and knowledge to specialists in the field of oncology. The student will also be able to critically and autonomously elaborate original ideas in a clinical research context and to interpret and formulate judgments on current clinical trials in oncology.

4. Communication skills
The modality of interactive lessons with seminars held by specialists in oncology (from diagnostics to therapy) will allow students to stimulate their critical and communicative skills. In the view of transformation of pharma companies, with the exponential growth of molecularly targeted drugs, a thorough knowledge of precision medicine in oncology will be extremely useful .

5. Learning skills
In the age of precision medicine the student will become aware of how indispensable for professional purposes is a continuous updating in a field, such as oncology, in which innovation in the pharmacological research it is in continuous evolution, with the development of always new targeted agents in the view of a more and more precise personalization of the treatments in oncology.

10612253 | CHEMISTRY OF COSMETIC PRODUCTS5th1st6ITA

Educational objectives

General expected learning outcomes
The Chemistry of Cosmetic Products course aims to teach the student the main types of cosmetic products and their use, the function of the different categories of ingredients used in the preparation of cosmetic products, the formulation aspects and the legislative aspects concerning the conception, production and sale of cosmetic products and the social and economic aspects related to their use.

Specific expected learning outcomes
1. Knowledge and understanding
The student will learn the function of each ingredient of a cosmetic product, the specific functions of the same ingredient in the main classes of cosmetic products, the physiological variation that the ingredients can exert in the area of application. He will learn the origin and composition of the main categories of ingredients and the techniques for their preparation and extraction. In particular, he will know the various types of lipid phases, their origin and their different functions in the various cosmetics, the surfactants and their use as detergents and dispersants, the water used in cosmetic products and the main hydrophilic ingredients, as well as other specific ingredients such as preservatives and antioxidants. He will also know the legislative aspects related to the use of the various ingredients and to the cosmetic product as a whole.

2. Applying knowledge and understanding
At the end of the course, the student will be able to recognize, for a cosmetic formulation, the functions of each ingredient and to critically evaluate the possible interactions, incompatibilities, synergies of the various ingredients. He will be able to evaluate the stability of the formulation according to the substances contained. He will be able to propose a choice of ingredients relating to the effect to be obtained, and the conditions of use of the cosmetic product.

3. Making judgements
The lessons will involve the direct participation of the students by asking and soliciting questions in order to stimulate their critical sense. Comparison of the ingredients also suitable for nutrition will also be proposed, stimulating the ability to correlate the various functions that an ingredient can have in the various fields of use. Notions already acquired in the chemical field (inorganic, organic and biochemical chemistry) and in the biomedical field (anatomy, physiology, pathology, pharmacology, toxicology) will be recalled.

4. Communication skills
The evaluation of the student preparation will be by oral examination, which will focus on all the topics of the program, testing the student's communication skills.

5. Learning skills
The student will be encouraged to seek further information on topics of interest both in the recommended texts and in specific scientific publications on the subject. This exercise will be useful also for his future working experience, to build skills in context analysis and problem solving.

10612254 | NANOSYSTEMS FOR THE DIAGNOSIS AND THE PHARMACEUTICAL TECHNOLOGY5th1st6ITA

Educational objectives

General expected learning outcomes
The course aims to illustrate the applications of nanotechnologies to sensors and in the pharmaceutical and therapeutic field. At the end of the course, students will be able to understand how to synthesize, characterize and manipulate nanomaterials and how they can be used to create new nano-biodevices for diagnostics and as carriers for pharmaceutical applications and biomedicine.

- Nanosystems for the diagnosis and the pharmaceutical technology I
The aim of the nanosystems module is to provide students with the necessary information for a critical knowledge of the principles and applications of nanotechnologies ranging from the creation and modification of nanostructured material, to kinetics, electrochemistry and the principles of plasmon resonance, together with the knowledge acquired in other lessons such as biochemistry, organic chemistry and pharmacology will be the basis for the realization of miniaturized devices based on bio-nanotechnologies applied to resolutions of problems in the food, clinical and ecotoxicological fields.
KNOWLEDGE AND UNDERSTANDING ABILITY:
• to know the principles that underlie nanotechnology with particular regard to modification and functionalization;
• to know the principles underlying the measurement techniques applied for the realization of the nanodevices;
• to understand the potentiality of nanostructured modified biosensors and their use in real matrices analysis in several fields of interest in particular; food, clinical, pharmaceutical and environmental.
ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING:
• to understand the different theoretical-experimental approaches for the resolution of properties inherent in the use of nanomaterials in diagnostics in general and biosensors in particular.
JUDGMENT AUTONOMY:
• to be able to develop their critical sense following stimuli coming from the teacher:
• to be able to connect the topics studied thanks to the multidisciplinary nature of the course by integrating what has been studied in the course with the already acquired knowledge of the chemical and biological type.
LEARNING ABILITY:
• to be able to describe scientific topics related to real systems using in a critical way the methodologies and techniques covered in the course.
COMMUNICATION SKILLS:
• to be able to discuss scientific topics related to nanotechnologies and measuring devices and apply them to real processes.

- Nanosystems for the diagnosis and the pharmaceutical technology II
The aim of this module is to illustrate the applications of the nanotechnologies in the pharmaceutical and biomedical field. In particular, the main applications of nanotechnologies in drug delivery, medicine and theranostics will be showed, both for systems under already on the market and for the most innovative systems in the early research stage.

This aim will be reached through the achievement of specific objectives concerning:
• The description of the main nanotechnological systems developed and under research, with an illustration of their structure and of the rationale underlying their application;
• the knowledge of the national and international regulatory bases for nanotechnological products;
• the knowledge of the main formulations and production of nanotechnological products;
• the ability to systematically apply the knowledge acquired in the course to the various operational contexts in which the student, once he has obtained his degree, will operate;
• the ability to communicate the results of their own elaborations to the stakeholders;
• the ability to find information necessary for the self-updating.

These specific objectives will be achieved through the provision of lectures, the execution of group work and the preparation of written reports.

NANOSYSTEMS FOR THE DIAGNOSIS AND THE PHARMACEUTICAL TECHNOLOGY I5th1st3ITA

Educational objectives

The aim of this module is to illustrate the applications of the nanotechnologies in the pharmaceutical and biomedical field. In particular, the main applications of nanotechnologies in drug delivery, medicine and theranostics will be showed, both for systems under already on the market and for the most innovative systems in the early research stage.

This aim will be reached through the achievement of specific objectives concerning:
• The description of the main nanotechnological systems developed and under research, with an illustration of their structure and of the rationale underlying their application;
• the knowledge of the national and international regulatory bases for nanotechnological products;
• the knowledge of the main formulations and production of nanotechnological products;
• the ability to systematically apply the knowledge acquired in the course to the various operational contexts in which the student, once he has obtained his degree, will operate;
• the ability to communicate the results of their own elaborations to the stakeholders;
• the ability to find information necessary for the self-updating.

These specific objectives will be achieved through the provision of lectures, the execution of group work and the preparation of written reports.

NANOSYSTEMS FOR THE DIAGNOSIS AND THE PHARMACEUTICAL TECHNOLOGY II5th1st3ITA

Educational objectives

The aim of the nanosystems module is to provide students with the necessary information for a critical knowledge of the principles and applications of nanotechnologies ranging from the creation and modification of nanostructured material, to kinetics, electrochemistry and the principles of plasmon resonance, together with the knowledge acquired in other lessons such as biochemistry, organic chemistry and pharmacology will be the basis for the realization of miniaturized devices based on bio-nanotechnologies applied to resolutions of problems in the food, clinical and ecotoxicological fields.
KNOWLEDGE AND UNDERSTANDING:
• to know the principles that underlie nanotechnology with particular regard to modification and functionalization;
• to know the principles underlying the measurement techniques applied for the realization of the nanodevices;
• to understand the potentiality of nanostructured modified biosensors and their use in real matrices analysis in several fields of interest in particular; food, clinical, pharmaceutical and environmental.
APPLYING KNOWLEDGE AND UNDERSTANDING:
• to understand the different theoretical-experimental approaches for the resolution of properties inherent in the use of nanomaterials in diagnostics in general and biosensors in particular.
MAKING JUDGMENTS:
• to be able to develop their critical sense following stimuli coming from the teacher:
• to be able to connect the topics studied thanks to the multidisciplinary nature of the course by integrating what has been studied in the course with the already acquired knowledge of the chemical and biological type.
LEARNING SKILLS:
• to be able to describe scientific topics related to real systems using in a critical way the methodologies and techniques covered in the course.
COMMUNICATION SKILLS:
• to be able to discuss scientific topics related to nanotechnologies and measuring devices and apply them to real processes.

1026798 | BIOINORGANIC CHEMISTRY5th1st6ITA

Educational objectives

General expected learning outcomes
The objective of the Bioinorganic Chemistry course is to teach the role of inorganic elements in biological, environmental, and pharmaceutical processes. This discipline utilizes tools and deepens concepts borrowed from the fields of chemistry, physics, biology, and medicine.

Specific expected learning outcomes
1. Knowledge and understanding
The student will learn about the selection, accumulation, transport, and storage of inorganic elements in organisms, particularly metal ions, and will understand the reaction mechanisms at the molecular level in which they participate in numerous physio-pathological processes. Specifically, concepts related to coordination chemistry principles; the selection, absorption, and organization of metal-containing units in biology; the toxic effects of inorganic elements, including Mercury, Chromium, Arsenic, Lead; the structure and functions of the heme unit; the properties of Iron and Copper in oxygen-carrying proteins; the role of Zinc in hydrolytic enzymes; metal-mediated enzymatic atom and electron transfer reactions; inorganic elements in drugs; and the toxic and therapeutic potential of small molecules (NO, CO, H2S) are described and discussed.

2. Applying knowledge and understanding
At the end of the course, the student will know the main roles played by inorganic elements and metals in biology and medicine and will be able to discuss their importance in the treatment and diagnosis of various diseases.

3. Making judgements
The lectures will be interactive with questions and prompts aimed at stimulating attention, making connections, and encouraging critical considerations based on already acquired concepts and tools. The goal is to rework the learned notions and material obtained from bibliographic research in international journals and specialist texts in a clear and synthetic manner.

4. Communication skills
To this end, the course includes the development of a monographic theme by each student and the related oral presentation in the presence of colleagues and potentially other interested parties.

5. Learning skills
The student will be able to study and deepen the topics covered in the lectures using the material provided by the lecturer on the e-learning platform (slides; scientific articles and reviews) and consulting the recommended textbooks (some copies are available in the Department library).

10612259 | ADVANCED ORGANIC SYNTHESIS5th1st6ITA

Educational objectives

General expected learning outcomes
Organic chemistry is a chemistry discipline involving the scientific study of the structure, reactivity, properties and applications of compounds which are formed mainly by carbon atoms, forming covalent bonds, both from natural and artificial sources.
The general objective of the SACO course, is to provide students with the knowledge and the competences necessary to understand and apply the key principles of the stereoselective and metal-assisted synthetic routes, touching the main topics studied and acquired during the Organic Chemistry 1 and Organic Chemistry 2 classes. For a CTF student this learning is essential, because most of the synthetic methodology of biologically active compound are based on stereoselective and/or metal-assisted processes. This knowledge will allow the student to be able to understand the new synthetic methodology involved in the construction of biologically active compounds. Furthermore, acquiring of advanced knowledge about organic chemistry will be essential for improving the understanding of the drug-receptor interactions, a crucial topic in different next courses.

Specific expected learning outcomes
The SACO course is devoted to provide students with the adequate knowledge to be independent in solving problems about specific organic chemistry studies. This ability will be acquired by the means of frontal lesson, submitting to the students illustrative case studies about the synthesis of biologically active compounds.
Teaching materials, available on line will support students during the lessons even thought studying the recommended text book is essential to acquire the skills and the competence that are necessary to perform the final exam.
In order to improve the exposure ability, students will be constantly encouraged to communicate their ideas to both specialists and non specialists audiences. The Erasmus programme will enable students to improve their communications skills, by exchanging information, problems and solutions.
The specific objectives consist in acquiring the following knowledge and expertise:
1) to understand advanced stereochemistry and its importance on the reactivity of organic compounds;
2) to acquire the specific knowledge to understand the main stereoselective reactions;
3) to acquire the specific knowledge to understand the main metal-assisted synthetic procedures; 4) introduction to the bioorganic reaction
5) to acquire the specific knowledge to perform retrosynthetic analysis on molecules of intermediate structural complexity.
7) to acquire the specific knowledge to understand the molecular structure through NMR.

10612256 | ADVANCED SEPARATION AND SPECTROSCOPIC METHODS IN ORGANIC CHEMISTRY5th1st6ITA

Educational objectives

General expected learning outcomes
This course is mainly designed to provide a deeper insight into advanced chromatographic and spectrometric techniques presented during the course of Physical Methods in Organic Chemistry (second semester of the third year). Chromatographic techniques allow the qualitative and quantitative determination of complex mixtures, obtained both from synthetic processes and from extractive processes from vegetable drugs and environmental matrices. For these reasons, such techniques play a fundamental role for a future employment in the field of regulatory affairs and healthcare industries.
The students will experience the most modern techniques for the separation of complex mixtures (HPLC, UHPLC, HILIC) and the basic concepts of the coupling between liquid chromatography and mass spectrometry (LC/MS), aimed at the correct identification of the chemical structure of the studied compounds.

Specific expected learning outcomes
1. Knowledge and understanding
At the end of the course the student has a thorough and advanced knowledge of the chromatographic and spectroscopic methods already presented in the course of Physical Methods in Organic Chemistry. He knows the most modern techniques for the separation of complex mixtures (HPLC, UHPLC, HILIC) and the basic concepts of the coupling between liquid chromatography and mass spectrometry (LC/MS).

2. Applying knowledge and understanding
At the end of the course the student knows the most widely used chromatographic materials, the theoretical principles and the most innovative chiral stationary phases for the analysis of chiral drugs; he is familiar with the concept of the inversion of the elution order of enantiomers. He knows some of the most recent applications in the field of proteomics (monolithic capillary column approach) and of stereoselective molecular recognition in the gas phase.

3. Making judgements
At the end of the course the student is able to decide independently which analytical method is more useful to solve a particular trouble that he could meet in the working field, from the characterization of new active ingredients of therapeutic interest to the production and quality control of the drug.

4. Communication skills
At the end of the course the student has the ability to communicate outward the knowledge he has learned during the course, both toward the scientific community and the labor market. In particular, he must be able to provide clear and direct information on the most modern chromatographic techniques and their applications in the field of drugs.

5. Learning skills
The student who has passed the exam is able to continue the study by reading the most recent articles published in the literature that the teacher makes available to him on the e-learning platform. He/she is also able to check specific databases in the field.

10612260 | POLYMERS IN PHARMACEUTICALS5th1st6ITA

Educational objectives

General expected learning outcomes
The aim of the Course is to provide the fundamentals concerning the structure and behavior of polymeric materials and the ability to relate the polymer characteristics with their properties; to give an overview of the most important natural and synthetic polymers with a focus on the biomedical and pharmaceutical fields.

Specific expected learning outcomes
1. Knowledge and understanding
The student will know the different polymer categories according to the several methods used for their syntheses; as the different structures can influence their physico-chemical properties in the solid state and in solution. He will also know the main applications of each class of polymers in the industry with an important focus on the pharmaceutical and biomedical fields.

2. Applying knowledge and understanding
At the end of the classes the student will understand how the different polymers have specific applications, according to their different characteristics; which specific features are required to be a biomaterial for its use in a medical device or in an advanced pharmaceutical form. He will have the ability to plan the use of a specific polymer material in a pharmaceutical formulation, based on the required characteristics.

3. Making judgements
The student will be able to understand and critically evaluate the characteristics and use of the main polymer types for specific uses; he will be able to independently find information on the characteristics and use of polymers that he will meet during his study or his work, and he can choose the most suitable candidates for the various applications required.

4. Communication skills
The ability to communicate the acquired notions will be verified through direct discussions in the classroom and through the elaboration of a monograph related to a specific polymer or to a specific application to be illustrated by a presentation during the examination. Thanks to the course of Polymers for Pharmaceuticals the student will learn the specific basic terminology of the polymer science, he will be able to communicate on this subject in a suitable manner also at working level, where required.

5. Learning skills
The student will be stimulated through questions, interactive discussions and numerous connections to the field of pharmaceutical technology, in order to improve his ability to interdisciplinarity.

These specific objectives will be achieved through lessons and open discussion with reference to the most common polymers used and contained in pharmaceutical forms.

10612261 | PHARMACOLOGICAL ASSAYS5th1st6ITA

Educational objectives

GENERAL EXPECTED LEARNING OUTCOMES
The main aims of the course are to provide knowledge on experimental pharmacological techniques essential for drug development.

SPECIFIC EXPECTED LEARNING OUTCOMES
At the end of the course, students

1. Knowledge and understanding. Will know some experimental pharmacological techniques essential for pre-clinical and clinical drug development.

2. Applying knowledge and understanding. Will develop critical skills on the subjects of the course also thanks to the preparation of a short theoretical dissertation and visits to research centers .

3. Making judgements. Will have acquired autonomy of judgment thanks to the independent analysis of the bibliographic sources of the course before and after the lectures (flipped classroom).

4. Communication skills. Will improve his/her communication skills also thanks to the presentation of a dissertation and the final oral exam.

5. Learning skills. Will be familiar with the most modern bibliographic tools (databases, online texbooks of the platform ACCESS MEDICINE) which will allow her/him to stay updated on all frontier subjects in the field of pharmacology.

1022407 | PHARMACEUTICAL MICROBIOLOGY5th1st6ITA

Educational objectives

General expected learning outcomes
The course is aimed at deepening microbiological knowledge useful for the preparation of new drugs and their quality control and for microbiological control of cosmetics, mineral water, and food. The aim of the course is also to provide expertise for planning scientific research for the discovery of therapeutic targets against human pathogens.

Specific expected learning outcomes
1. Knowledge and understanding
The student will acquire skills to identify and to isolate the main human pathogens using the main classical microbiological, virological and molecular biology techniques, employed by diagnostic and research laboratories. Furthermore, the student will be able to suggest potential therapeutic targets, useful for the pharmacological treatment of various infectious diseases.

2. Applying knowledge and understanding
The student will be able to recognize the different microorganisms, to quantify the bacterial and viral load, and to perform the main sterilisation and biosafety procedures. The student will also be able to apply the main microbiological quality tests used in the cosmetics and pharmaceutic industry as well as in water and food control.

3. Making judgements
Lessons and laboratory exercises will be interactive. During the lessons the teacher will pursue an effective question strategy to capture students' attention, foster student involvement, and facilitate a positive, active learning environment. The student will be stimulated to analyse experimental data related to course topics.

4. Communication skills
At the end of the course the student will be able to use an appropriate technical-scientific language to communicate correctly on the topics covered, even with non-specialists or professionals from other disciplines.

5. Learning skills
The course is aimed at facilitating a critical and autonomous in-depth study of the topics covered in specialized texts and through consultation of databases and sector-specific platforms.

10612262 | DRUG DESIGN5th1st6ITA

Educational objectives

General expected learning outcomes
This course leads students towards a rational learning of Drug Design, giving them, after some general notes, a proper preparation about: a) targets, molecular interaction drug-target, consequences of these interactions basics of pharmacokinetic and pharmacodynamic; b) basics and strategies of drug design. Particular remarks will be on invention, discovery, design, identificatio, preparation of drugs, metabolism, molecular mechanism of action and structure-activity relationships.

Specific expected learning outcomes
1. Knowledge and understanding
The students will know and will be able to understand all aspects about pharmacokinetic and pharmacodynamic, drug targets, drug-target interactions, the consequences of these interactionsgeneral principles and strategies of drug discovery and design, the invention, discovery design identification of some specific drugs presented like case-studies, their metabolism, mechanism of action, and structure-activity relationships.

2. Applying knowledge and understanding
At the end of the course the student, applying the aquired knowledge, will be able to plan the design of a drug, starting form the decision about the therapeutic area, fenotypic approach, target based approach, study of drug-target interactions, hit to lead and lead to candidate development, going ahead to the application of synthetic strategies and technologies, including CADD, up to the right comprehension of the relevance of ADMA-Tox properties for strong candidate to the clinical development.

3. Making judgements
At the end of the course the student will be able to eavluate the appropriate approach to the design of a specific drug. This critical and judgement ability, will be obtained thanks to continuous interactivity hold during the course. In fact the teacher will ask questions very frequently to stimulate students to link the actual topics to all the topics studied up to that time, so that the study will not be isolated, but integrated matter with the aquired knowledge. At the end of the course the stundent will hold a presentation about an innovative recent drug.

4. Communication skills
The student will be able to communicate the knowledge comprehended by the course and will apply during the oral exam that will focus on the topics of the syllabus. The student is stimulated to communicate in an inteactive way during the classroom and, at the end of the course and after the exam, will be able to communicate effectively his/her knowledge in the drug design field to specialists and non-specialists, in a more technical and detailed, and in an educational way, respectively.

5. Learning skills
The student will find details of lessons on the suggested textbooks and in the scientific literature and will have ability to use them to pursue an indipendent preparation. This will be useful to teh studento to find again topics of the matte raso in future time when the memory of the concepts described in the lesson room will be softer. The textbooks will remain the benchmark for student that will be able to find again details of forgotten notions.

The student must acquire 2 CFU from the following exams
LessonYearSemesterCFULanguage
AAF2367 | STATE-OF-THE-ART RADIOPHARMACEUTICALS5th1st2ITA

Educational objectives

General expected learning outcomes
The course on the Use of Latest Generation Radiopharmaceuticals aims to illustrate to the student how radiopharmaceuticals have 'evolved' according to the criteria of precision medicine, managing to selectively irradiate tumor cells. Several innovative radiopharmaceuticals will be illustrated highlighting both the chemical structure and the mechanism of action. Furthermore, particular attention will be paid to the new frontier of theragnostics where diagnosis and therapy are combined in order to obtain the desired results with a single administration.

Specific expected learning outcomes
1. Knowledge and understanding
The student will be aware of all the aspects described above regarding the production (synthesis and labeling methods) of the main radiopharmaceuticals used for the osteoarticular system, for the pulmonary system, for the gastrointestinal system, for the urinary system and for the central nervous system.

2. Applying knowledge and understanding
At the end of the course the student will have knowledge of the importance of using a radiopharmaceutical in nuclear medicine. You will be able to recognize the mechanisms that link the detection system of a radiation emitted by a radiopharmaceutical with the identification of an ongoing pathological process either of inflammatory origin or inherent to the presence of a tumor form. You will be able to discriminate between the radiopharmaceuticals on the market, those to be used for diagnostic and/or therapeutic purposes. You will know the benefits and possible risks of using a radiopharmaceutical.

3. Making judgments
The lessons will all be frontal and interactive, during which the students will be stimulated to make connections with the various parts of the program carried out and with the notions previously acquired in the course of other teachings of the previous years. This in order to collectively involve the class in an active and critical way throughout the duration of the course.

4. Communication skills
The assessment of the student's learned notions will be carried out through a written test and possibly an oral test which will focus on all the topics of the program, testing the student's communication skills with respect to what she has learned.

5. Learning skills
The student will be able to independently continue the study of the subject thanks to a series of handouts provided by the teacher and recommended textbooks for further study. This will allow the student to always have the material available on which to review the topics covered.

AAF2433 | APPLICATIONS OF PRINCIPLES OF GENERAL AND INORGANIC CHEMISTRY5th1st2ITA

Educational objectives

General expected learning outcomes
The course aims to apply the principles of stoichiometry through numerical exercises. Problems relating to chemical reactions relevant to natural and industrial phenomena will be addressed, providing the student with the skills necessary for future experimental activities in the laboratory.

Specific expected learning outcomes
1. Knowledge and understanding
The student will acquire logical and calculation methods and knowledge of chemistry
useful for the study of weight relationships in chemical processes.

2. Applying knowledge and understanding
At the end of the course. the student will know the methods for: balancing chemical reactions; determine the concentrations of the solutions; calculate the quantities of reactants and products at equilibrium for homogeneous and heterogeneous systems and for acid/base reactions.

3. Making judgements
The lessons will be interactive and students will be able to make critical connections between the various topics.

4. Communication skills
During the course the student will acquire correct chemical terminology and learn to effectively present the topics covered and the calculation methods applied.

5. Learning skills
To study the topics covered in class, material and texts made available to the student will be published on the e-learning platform. The study method acquired during the course constitutes a solid basis for subsequent teachings.

AAF2368 | LABORATORY OF INNOVATIVE DRUGS AND BIOTECHNOLOGICAL DRUGS WITH ANTICANCER ACTIVITY5th1st2ITA

Educational objectives

General expected learning outcomes
In the course in “Innovative and biotechnological drugs with anticancer activity” the students will be hosted for a few days in a pharmaceutical synthesis laboratory to assist in the conduct of a small molecule synthesis process, from the design of a chemical reaction to its implementation, monitoring and processing. The mixture of products obtained will then be separated by identifying the product/products present in greater quantity with chemical-physical methods and subsequently characterizing it/them again with chemical-physical methods.

Specific expected learning outcomes
1. Knowledge and Understanding
The student will know all the practical aspects of a chemical-pharmaceutical synthesis. Fundamental notions will concern the study of the preparation, monitoring and processing of a chemical reaction conducted in a research laboratory, followed by the chemical-physical characterization of the identified molecules.

2. Applying knowledge and understanding
At the end of the course the student will be able to recognize the end of a synthetic chemical reaction, decide when to work it and decide the most appropriate method to separate the compounds obtained, to then characterize them with chemical-physical methods.

3. Making judgements
The teacher will ask the students continuous questions to stimulate them and develop their critical sense. These questions will also serve to evaluate and encourage students to make connections with everything studied up to now, avoiding considering the study of the subject as an end in itself but integrating medicinal chemistry in the light of the knowledge already acquired, both chemical (chemistry organic, biochemical) and biological (pathology, pharmacology, pharmacognosy, toxicology).

4. Communication skills
Students will be evaluated on a report (written test) which they will perform at the end of the period carried out in the research laboratory. The greater or lesser completeness of the report will give the measure of the score attributed.

5. Learning skills
The student will find the deepening of what he heard in class on scientific articles recommended by the teacher.

AAF2369 | ANALYTICAL METHODS FOR SPORTS DRUGS AND PSYCHOACTIVE SUBSTANCES5th1st2ITA

Educational objectives

General expected learning outcomes
The aim of Analisi delle sostanze dopanti e degli stupefacenti course is to provide the knowledge and understanding of instrumental analytical methodologies currently in use in the laboratories. In particular detailed knowledge of extractive procedures of different classes of dopant substances and new psycoactive substances and learning of instrumental analysis techniques useded for each class of doping agents and new psycoactive substances.

Specific expected learning outcomes
In this teaching, the students will have to acquire the following detailed skills according to Dublin descriptors:

1. Knowledge and understanding
Students acquire knowledge and understanding skills in analytical toxicology and doping control by learning the principles of analytical techniques in these fields.

2. Applying knowledge and understanding
The student will acquire the ability to correctly frame an analytical problem, with particular regard to the research for substances in biological fluids of different types and nature, and the ability to find information from the study of scientific bibliography in the context of the analysis of new psychoactive substances and of doping control, so as to be able to resolve the professional issues directly or indirectly linked to it.

3. Making judgements
The student will be independently able to identify among the procedures present in scientific articles the one suitable for identifying the substance of interest.

4. Communication skills
students acquire the ability to communicate knowledge, problems and solutions related to analytical toxicology and doping chemical analysis. They are also able to expose assessments and motivations in a clear and understandable way to specialists and non-specialists. The communicative ability derives from the right knowledge of the subjects and problems object of the communication. Comparison and interaction with the teacher develop these skills.

5. Learning skills
The student will be able to independently learn all the analytical techniques thanks to the availability of texts and handouts and also thanks to the consultation of scientific articles related to the topics of the course, which are published in indexed scientific journals.

AAF2370 | BIOCHEMICAL AND MOLECULAR BIOLOGY LABORATORY AND ACTIVITIES5th1st2ITA

Educational objectives

General expected learning outcomes
The main objective of the Laboratory and Biochemical and Molecular Biological Activities is to allow the student direct experience of biochemical, molecular biology and biotechnological techniques through attendance at laboratories in the above Research Area. Observation of the experimental work carried out in the laboratories will be useful in preparing him/her for the methodological approach, using the techniques observed, for the development, in a creative and inventive way, of new strategies of investigation, new diagnostic and therapeutic approaches.

Specific expected learning outcomes
1. Knowledge and understanding
The student during visit in the laboratories of biochemistry, molecular biology and biotechnology will deepen their knowledge of the techniques and methodologies and models of experimentation, in Biochemistry and Molecular Biology, applied to research (e.g., Cell Culture, Western blotting, PCR and Real-Time PCR Immunoprecipitation; Cloning and Expression Vectors in prokaryotes).

2. Applying knowledge and understanding
The students will know the most appropriate investigative strategies for research. They will be able to define critical points and those that can be implemented. They will know the application of specific instrumental methods and the methodological strategies used in conducting experimental work designed to identify new molecular targets for the development of new therapeutic treatments and diagnostic techniques, including biotechnology-based ones.

3. Making judgements
Students will be prompted to ask questions through analysis of what they have observed during the training activity. This will serve as an incentive for learners to work on synthesizing all the skills and knowledge acquired during their course and will stimulate their critical sense. They will acquire skills to use a scientific methodological approach to study and research activities, as well as collect and interpret experimental data related to issues in the field.

4. Communication skills
The training activity will involve continuous interaction with students will be able to present in the form of a report what has been observed in the laboratory, with particular reference to experimental methodologies. This mode will make it possible to assess the student's communication skills with regard to what has been learned during the course.

5. Learning skills
The student will be able to study in depth the activities and methodologies observed by consulting bibliographic material and databases specific to the field. The students will also develop the learning ability that will allow them to update their knowledge.

AAF2371 | PRECISION ONCOLOGY INSIGHTS5th1st2ITA

Educational objectives

General expected learning outcomes
The course is aimed to provide knowledge concerning precision medicine in oncology, focusing on main genomic, genic and molecular mechanisms implied in the pathogenesis of cancer, in order to give the theoretical basis for the development of new diagnostic, prognostic and therapeutic procedures in oncology.

Specific expected learning outcomes
1. Knowledge and understanding
During the course the student will acquire knowledge about precision oncology, specifically referring to genetic and epigenetic alterations of cancer, therapeutic targets ,molecular mechanisms of drug resistance in cancer therapy and development of agnostic drugs. This knowledge will be applied in the development of new targeted therapies in cancer. A further objective of the course is to equip the figure of the graduate in CTF with the basic theoretical tools for the understanding of clinical trials in oncology, of the research methodology, of the national legislation that governs its management.

2. Applying knowledge and understanding
The knowledge of the molecular mechanisms involved in cancer progression will make the student:
-able to link the alterations at the molecular level with the identification of new therapeutic targets
- possessing the appropriate skills to carry out both activities within the NHS's local pharmaceutical services and research activities;
- capable of independent judgment with reference to the evaluation, interpretation and reprocessing of literature data;
- able to elaborate in a critical and autonomous way original ideas in a biomedical research context;
- able to communicate the acquired information to specialists and non-specialists in the field of oncology.

3. Making judgements
The student will be able to independently collect and interpret data derived from scientific studies in oncology by reading scientific articles in English as well as to communicate information and knowledge to specialists in the field of oncology. The student will also be able to critically and autonomously elaborate original ideas in a clinical research context and to interpret and formulate judgments on current clinical trials in oncology.

4. Communication skills
The modality of interactive lessons with seminars held by specialists in oncology (from diagnostics to therapy) will allow students to stimulate their critical and communicative skills. In the view of transformation of pharma companies, with the exponential growth of molecularly targeted drugs, a thorough knowledge of precision medicine in oncology will be extremely useful.

5. Learning skills
In the age of precision medicine the student will become aware of how indispensable for professional purposes is a continuous updating in a field, such as oncology, in which innovation in the pharmacological research it is in continuous evolution, with the development of always new targeted agents in the view of a more and more precise personalization of the treatments in oncology.

AAF2372 | INSIGHT INTO COSMETIC CHEMISTRY5th1st2ITA

Educational objectives

General expected learning outcomes
The course aims to extend the basic knowledge of cosmetic products acquired with the Chemistry of Cosmetic Products course, addressing more particular and complex categories of cosmetic products and studying more specific categories of ingredients used in their formulation.

Specific expected learning outcomes
1. Knowledge and understanding
The student will learn the chemistry and the function of specific ingredients used in particular cosmetics with more complex formulations. In particular, he will know the substances used in sun protection, together with the physiological aspects associated with it, the anti-aging cosmetics, and the products for the make-up; an insight into polymeric ingredients will also be provided. He will also know the legislative aspects related to the use of these ingredients and to the cosmetic product as a whole.

2. Applying knowledge and understanding
At the end of the course, the student will be able to recognize the functions of the ingredients also for a complex cosmetic formulation and to critically evaluate the possible interactions, incompatibilities, synergies of the various ingredients. He will be able to evaluate the stability of the formulation according to the substances contained. He will be able to propose a choice of ingredients relating to the effect to be obtained, and the conditions of use of the cosmetic product.

3. Making judgements
The lessons will involve the direct participation of the students by asking and soliciting questions in order to stimulate their critical sense. Notions already acquired in the chemical (inorganic, organic and biochemical chemistry), biomedical (anatomy, physiology, pathology, pharmacology, toxicology) and cosmetic fields will be recalled.

4. Communication skills
The evaluation of the student preparation will be carried out by oral examination, which will focus on all the topics of the program, testing the student's communication skills.

5. Learning skills
The student will be encouraged to seek further information on topics of interest both in the recommended texts and in specific scientific publications on the subject. This exercise will be useful also for his future working experience, to build skills in context analysis and problem solving.

AAF2373 | NANOTECHNOLOGY PRACTICE5th1st2ITA

Educational objectives

General expected learning outcomes
The laboratory exercises will illustrate the preparation of some nanomaterials and their electrochemical, optical, and electron microscopic characterization. Exercises will also be carried out to describe the various phases of the realization of electrochemical biosensors and nanosystems for drug delivery and subsequent characterization measurements, as well as data processing methods.

Specific expected learning outcomes
1. Knowledge and understanding
The knowledge acquired during the exercises will allow the understanding of:
• principles underlying nanotechnologies with particular regard to the preparation, modification, and functionalization of nanosystems;
• principles underlying nanodevice characterization techniques;
• potential of nanosystems and their use in analyzing real matrices of food, clinical, pharmaceutical, and environmental interest.

2. Applying knowledge and understanding
This knowledge comes from attending the nanosystems for diagnostics and pharmaceutical technology course:
• principles underlying nanotechnologies with particular regard to the preparation, modification and functionalization of nanosystems;
• principles underlying nanodevice characterization techniques;
• understanding the potential of nanosystems and their use in the analysis of real matrices of food, clinical, pharmaceutical and environmental interest.

3. Making judgements
• be able to develop one's own critical sense following stimuli from the teacher:
• be able to connect the topics studied thanks to the multidisciplinary nature of the course, integrating what has been studied in the course with the knowledge acquired during the laboratory exercises.

4. Communication skills
• be able to discuss scientific topics related to nanotechnologies and measuring devices and apply them to real processes.

5. Learning skills
• Be able to describe scientific issues related to real systems using the methodologies and techniques covered in the course critically.

AAF2374 | MASS SPECTROMETRY APPLIED TO BIOINORGANIC CHEMISTRY5th1st2ITA

Educational objectives

General expected learning outcomes
The objective of the course on Mass Spectrometry Applied to Bioinorganic Chemistry is to provide the tools to design, execute, and interpret the results of an experimental approach based on mass spectrometry for studying issues related to bioinorganic chemistry. This discipline draws on basic concepts from inorganic chemistry, biochemistry, and the relevant analytical technology, mass spectrometry.

Specific expected learning outcomes
1. Knowledge and understanding
The student will learn about the most recent analytical techniques based on mass spectrometry for identifying and characterizing biologically significant species containing transition metals, including metallopharmaceuticals and metalloenzymes.

2. Applying knowledge and understanding
At the end of the course, the student will be familiar with the main mass analyzers used for studying metallic species and will be able to define the pros and cons of different ionization sources used for sampling metallopharmaceuticals and metalloproteins, selecting them based on the characteristics of the analytes of interest. The student will also be capable of interpreting complex mass spectra.

3. Making judgements
The lectures will be interactive, with questions and prompts designed to stimulate attention, make connections, and encourage critical considerations based on concepts and tools already acquired through exercises and laboratory experiences. The goal is to rework the learned notions and material obtained from bibliographic research in international journals and specialist texts in a clear and synthetic manner.

4. Communication skills
To this end, the course includes the development of a monographic theme by each student and the related oral presentation in the presence of colleagues and potentially other interested parties.

5. Learning skills
The student will be able to study and deepen the topics covered in the lectures using the material provided by the lecturer on the e-learning platform (slides, scientific articles, and reviews) and consulting the recommended textbooks (some copies are available in the Department library).

AAF2375 | DESIGN SYNTHESIS PURIFICATION AND STRUCTURAL CHARACTERIZATION OF A HETEROCYCLIC COMPOUND5th1st2ITA

Educational objectives

General expected learning outcomes
The module aims to initiate students to experimental research work in organic chemistry, consisting in the design, synthesis, purification and structural characterization of a heterocyclic compound. The module is closely linked to the knowledge imparted in the Advanced Synthesis course in Organic Chemistry, in which all the necessary knowledge is provided to deal competently with the related activities and which represents, albeit not exclusively, the cultural prerequisite for being able to follow it profitably.

Specific expected learning outcomes
The module is divided into the following two sections:
1. 0.5 credits of lectures during which the problem relating to the design of a molecule belonging to the class of heterocyclic compounds will be addressed. The problem will be examined in the light of the main synthetic methodologies, classic and innovative, of the organometallic and organocatalytic type, with particular attention to the stereochemical aspects.

2. 1.5 CFU of experimental activities during which the designed molecule will be synthesized, purified and structurally characterized. Syntheses will be performed using both classical and innovative methodologies, such as solid phase synthesis, microwave assisted synthesis or flow chemistry. Purification activities will be carried out using standard systems, such as flash chromatography, or advanced ones, such as semi-preparative HPLC, both in direct and reverse phase. Structural characterization will be performed by one- and two-dimensional NMR analysis and GC-MS or LC-MS.

AAF2376 | INTERPRETATION OF MASS SPECTRA OF MODEL DRUGS5th1st2ITA

Educational objectives

General expected learning outcomes
The general expected learning outcome of this 2 CFU course is to provide a thorough knowledge of the ChemDraw software for the design of organic molecules and the prediction of the most frequent molecular fragmentations that occur in a mass spectrometer (use of the ChemDraw "mass fragmentation" command). The acquired knowledge will be applied by the students to interpret the ESI mass spectra of model drugs (offered by the teacher), by attributing the different peaks in the spectrum to specific fragments produced within the ionization source.

Specific expected learning outcomes
1. Knowledge and understanding
At the end of the course the student has a thorough knowledge of the ChemDraw software for the design of organic molecules and the prediction of the most frequent molecular fragmentations that occur in a mass spectrometer (use of the ChemDraw "mass fragmentation" command).

2. Applying knowledge and understanding
At the end of the course the student is able to interpret an ESI mass spectrum of a model drug and to attribute the different peaks present in the spectrum to specific fragments produced within the ionization source.

3. Making judgements
At the end of the course the student is able to independently decide which analytical method is more useful to solve a particular trouble he may meet in the working field, from the characterization of new active ingredients of therapeutic interest to the production and quality control of the drug.

4. Communication skills
At the end of the course the student has the ability to communicate the knowledge he has learned during the course to the outside world, both with regard to the scientific community and the world of work. In particular, he/she must be able to present information relating to mass spectrometry and its possible application to the field of drugs in a clear and straight way.

5. Learning skills
The student who has passed the exam is able to continue the study by reading the most recent articles published in the literature that the teacher makes available to him/her on the e-learning platform. He/she is also able to check specific databases in the field of drugs.

AAF2377 | POLYMER PRACTICE5th1st2ITA

Educational objectives

General expected learning outcomes

The aim of the course is to extend the knowledge acquired with the course "Polymers in Pharmaceuticals" through a more experimental approach to polymer science, with practice on the characterization of polymer materials and their formulations.

Specific expected learning outcomes

1. Knowledge and understanding

The student will know the main characterization techniques of polymers and their formulations, through lessons and laboratory practice. He will understand how polymer structures affect the properties in solution and in the solid state, as well as the polymer formulations.

2. Applying knowledge and understanding

At the end of the course, the student will know the basic techniques for the polymer characterization and he will understand how to analyze different polymers based on the properties of interest for their pharmaceutical application

3. Making judgements

The student will be able to understand and critically evaluate the characteristics of important polymers and he will be able to choose the most suitable candidates for the various applications required.

4. Communication skills

With the “Polymer Practice” course, the student will learn the specific terminology of the polymer characterization, and he will be able to communicate on this subject in a suitable manner also at working level.

5. Learning skills

The student will be stimulated to understand how different experimental techniques can give information on the nature and properties of polymers and will be stimulated to apply his knowledge in an interdisciplinary way.

AAF2378 | LABORATORY OF PHARMACOLOGICAL ASSAYS5th1st2ITA
AAF2366 | SCREENING OF ANTIMICROBIAL COMPOUNDS5th1st2ITA

Educational objectives

General expected learning outcomes
The course aims to deepen the microbiological knowledge required to screen synthetic or naturally occurring molecules with potential antimicrobial activity in in vitro models. The course also aims to provide skills for the design of new pharmaceutical forms with antimicrobial activity.

Specific expected learning outcomes
1. Knowledge and understanding
At the end of the course, the student will acquire skills to perform the main cytotoxicity, microbial count, and viral titration assays, to test molecules with potential antimicrobial activity. Furthermore, the student will be able to suggest potential therapeutic targets, useful for the pharmacological treatment of infectious diseases.

2. Applying knowledge and understanding
At the end of the course, the student will acquire skills in the main microbiological and virological, cellular and molecular biology techniques through practical laboratory exercises.
In addition, the student will acquire skills in the development of potential new drugs with antimicrobial activity, based on multidisciplinary expertise.

3. Making judgements
Lessons and laboratory exercises will be interactive. The student will be stimulated to develop a critical sense, to make critical judgements, to collect and interpret experimental data and to follow the biosafety rules to be used in the laboratory.

4. Communication skills
At the end of the course, the student will be able to use an appropriate technical-scientific language, which will allow him/her to communicate correctly on the topics covered, also with non-specialists and professionals from other disciplines.

5. Learning skills
At the end of the course, the student will acquire the ability to critically and independently investigate the various topics addressed during lessons and practical laboratory activities in specialized texts and by consulting sector-specific databases and platforms.

AAF2379 | INDUSTRIAL SYNTHESIS OF DRUGS5th1st2ITA
AAF2385 | INTERNSHIP IN RESEARCH INSTITUTIONS AND COMPANIES5th1st2ITA

Educational objectives

General expected learning outcomes
The internship, in public or private institutions and in companies involved in health and well-being research area, aims to allow the student to acquire detailed and in-depth outcomes, both theoretical and practical, in strategic and specialization Health & Biopharma area.

Specific expected learning outcomes
1. Knowledge and understanding
Depending on the institutuion or company chosen, the student will know and understand specific aspects relating to the design, production, development, marketing and commercialization of health and well-being products.

2. Applying knowledge and understanding
At the end of the internship, the student will be able to apply the knowledge acquired to solve problems in their field of study and will have acquired adequate skills to devise and support arguments in the specific sector in which the internship was carried out.

3. Making judgements
At the end of the internship, the student will be able to formulate an analytical/critical judgment on the topics covered, collect and interpret useful data for their studies and apply the concepts explored during the internship to scientific knowledge in the health and well-being resrach area.

4. Communication skills
Through the acquisition of the skills acquired during the internship, the student will be able to communicate information, ideas, problems and solutions with greater depth of knowledge and technical-scientific language to specialist and non-specialist interlocutors.

5. Learning skills
The student who acquired the skills above described will be able to carry out future studies with a greater degree of autonomous autonomy and to propose topics useful for the scientific progress of society in the field of health and well-being in social and/or work contexts.